@article{oai:repo.qst.go.jp:00083030,
 author = {Kei, Oyama and Yukiko, Hori and Yuji, Nagai and Naohisa, Miyakawa and Koki, Mimura and Toshiyuki, Hirabayashi and Inoue, Ken-ichi and Tetsuya, Suhara and Takada, Masahiko and Makoto, Higuchi and Takafumi, Minamimoto and Kei, Oyama and Yukiko, Hori and Yuji, Nagai and Naohisa, Miyakawa and Koki, Mimura and Toshiyuki, Hirabayashi and Tetsuya, Suhara and Makoto, Higuchi and Takafumi, Minamimoto},
 issue = {26},
 journal = {Science Advances},
 month = {Jun},
 note = {The primate prefrontal cortex (PFC) is situated at the core of higher brain functions via neural circuits such as those linking the caudate nucleus and mediodorsal thalamus. However, the distinctive roles of these prefronto-subcortical pathways remain elusive. Combining in vivo neuronal projection mapping with chemogenetic synaptic silencing, we reversibly dissected key pathways from dorsolateral part of the PFC (dlPFC) to the dorsal caudate (dCD) and lateral mediodorsal thalamus (MDl) individually in single monkeys. We found that silencing the bilateral dlPFC-MDl projections, but not the dlPFC-dCD projections, impaired performance in a spatial working memory task. Conversely, silencing the unilateral dlPFC-dCD projection, but not the unilateral dlPFC-MDl projection, altered preference in a decision-making task. These results revealed dissociable roles of the prefronto-subcortical pathways in working memory and decision-making, representing the technical advantage of imaging-guided pathway-selective chemogenetic manipulation for dissecting neural circuits underlying cognitive functions in primates.},
 title = {Chemogenetic dissection of the primate prefronto-subcortical pathways for working memory and decision-making},
 volume = {7},
 year = {2021}
}