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Metabolic Tumor Volume of Methionine PET in Early Lung Cancer is Useful for Predicting Prognosis of Patients treated with Carbon Ion Radiotherapy
https://repo.qst.go.jp/records/82932
https://repo.qst.go.jp/records/82932dd60d130-bc6f-4372-8519-9521b17ad679
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-06-04 | |||||
| タイトル | ||||||
| タイトル | Metabolic Tumor Volume of Methionine PET in Early Lung Cancer is Useful for Predicting Prognosis of Patients treated with Carbon Ion Radiotherapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kentaro, Tamura
× Kentaro, Tamura× Ryuichi, Nishii× Kana, Yamazaki× Naoyoshi, Yamamoto× Tatsuya, Higashi× Hiroshi, Tsuji× Kentaro, Tamura× Ryuichi, Nishii× Kana, Yamazaki× Naoyoshi, Yamamoto× Tatsuya, Higashi× Hiroshi, Tsuji |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Objectives: Lung cancer is one of the most prevalent cancers worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85-90% of all lung tumor types. Carbon ion radiation therapy (CIRT) has achieved outcomes comparable to surgery due to its excellent dose-concentration and high biological effectiveness. However, two-year progression-free survival of patients treated with CIRT for locally advanced lung cancer is reported as 40%. C11-methionine (MET) is an amino acid radiotracer known to show tumor-specific accumulation and MET-PET/CT imaging is useful in evaluating lung tumors. However, the correlation between MET-PET/CT imaging biomarkers and prognosis in NSCLC patients is still unknown. The aim of this study was to investigate the predictive values of MET-PET/CT in patients treated with CIRT for NSCLC. Methods: Sixty consecutive patients (36 males and 24 females; mean age 73.3y; range 51-89y) with locally advanced NSCLC who underwent MET-PET/CT prior to CIRT between 2007 and 2012 were enrolled. Patients were treated with 40-50 Gy of CIRT. The mean follow-up period was 77.3 months. For quantitative analysis of PET image data, metabolic tumor volume was obtained with a threshold of standardized sptake value (SUV) greater than 1.5. Tumor contouring on MET-PET/CT image was determined by a consensus of two board-certified diagnostic radiologists. Univariate and Multivariate Cox proportional hazard regression analyses and Kaplan-Meir analyses were performed to assess the predictive value for disease-free survival (DFS) among a diameter of solid tumor component (Solid-Diameter), SUVmax, Metabolic Tumor Volume (MTV), Total Lesion Metabolism of the amino acid (TLM), and clinical factors. Statistical analyses were calculated with SPSS statistical software, version 26 with P values of less than 0.05 considered statistically significant. Results: The mean SUVmax of the tumor was 3.53±1.0. Univariate Cox proportional hazard regression analyses showed that SUVmax (p<lt;0.05, HR 3.22 95% CI 1.21-8.56), MTV (p<lt;0.005, HR 4.45, 95% CI 1.78-11.2), and TLM (p<lt;0.005, HR 0.249, 95% CI 0.10-0.62) were significant prognostic factors for DFS. While, the Solid-Diameter, age, sex, and the treatment radiation dose were not significant prognostic factors for DFS. After checking multicollinearity, multivariate Cox hazard analysis was performed with five elements: Solid-Diameter, SUVmax, MTV, age, and sex. MTV was revealed to be the only independent prognostic factor (p<lt;0.05, HR 0.257, 95% CI 0.072-0.923). Kaplan-Meier analysis of MTV demonstrated that patients with MTV lower than 6ml had longer DFS (p<lt;0.001). Conclusions: Metabolic Tumor Volume (thresholds of SUV 1.5) in MET-PET/CT would be a useful predictor of disease-free survival of NSCLC treated with CIRT. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | SNMMI 2021 Annual Meeting | |||||
| 発表年月日 | ||||||
| 日付 | 2021-06-11 | |||||
| 日付タイプ | Issued | |||||
