{"created":"2023-05-15T15:01:07.942427+00:00","id":82932,"links":{},"metadata":{"_buckets":{"deposit":"6bfaffdc-06da-4ee1-900f-3519bcc62463"},"_deposit":{"created_by":1,"id":"82932","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82932"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082932","sets":["10:28"]},"author_link":["994319","994313","994314","994312","994315","994308","994309","994317","994318","994311","994310","994316"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2021-06-11","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Objectives: Lung cancer is one of the most prevalent cancers worldwide, and non-small cell lung cancer (NSCLC) accounts for about 85-90% of all lung tumor types. Carbon ion radiation therapy (CIRT) has achieved outcomes comparable to surgery due to its excellent dose-concentration and high biological effectiveness.\nHowever, two-year progression-free survival of patients treated with CIRT for locally advanced lung cancer is reported as 40%. C11-methionine (MET) is an amino acid radiotracer known to show tumor-specific accumulation and MET-PET/CT imaging is useful in evaluating lung tumors. However, the correlation between MET-PET/CT imaging biomarkers and prognosis in NSCLC patients is still unknown. The aim of this study was to investigate the predictive values of MET-PET/CT in patients treated with CIRT for NSCLC.\nMethods: Sixty consecutive patients (36 males and 24 females; mean age 73.3y; range 51-89y) with locally advanced NSCLC who underwent MET-PET/CT prior to CIRT between 2007 and 2012 were enrolled. Patients were treated with 40-50 Gy of CIRT. The mean follow-up period was 77.3 months. For quantitative analysis of PET image data, metabolic tumor volume was obtained with a threshold of standardized sptake value (SUV) greater than 1.5. Tumor contouring on MET-PET/CT image was determined by a consensus of two board-certified diagnostic radiologists. Univariate and Multivariate Cox proportional hazard regression analyses and Kaplan-Meir analyses were performed to assess the predictive value for disease-free survival (DFS) among a diameter of solid tumor component (Solid-Diameter), SUVmax, Metabolic Tumor Volume (MTV), Total Lesion Metabolism of the amino acid (TLM), and clinical factors. Statistical analyses were calculated with SPSS statistical software, version 26 with P values of less than 0.05 considered statistically significant.\nResults: The mean SUVmax of the tumor was 3.53±1.0. Univariate Cox proportional hazard regression analyses showed that SUVmax (p<lt;0.05, HR 3.22 95% CI 1.21-8.56), MTV (p<lt;0.005, HR 4.45, 95% CI 1.78-11.2), and TLM (p<lt;0.005, HR 0.249, 95% CI 0.10-0.62) were significant prognostic factors for DFS. While, the Solid-Diameter, age, sex, and the treatment radiation dose were not significant prognostic factors for DFS. After checking multicollinearity, multivariate Cox hazard analysis was performed with five elements: Solid-Diameter, SUVmax, MTV, age, and sex. MTV was revealed to be the only independent prognostic factor (p<lt;0.05, HR 0.257, 95% CI 0.072-0.923). Kaplan-Meier analysis of MTV demonstrated that patients with MTV lower than 6ml had longer DFS (p<lt;0.001).\nConclusions: Metabolic Tumor Volume (thresholds of SUV 1.5) in MET-PET/CT would be a useful predictor of disease-free survival of NSCLC treated with CIRT.\n","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"SNMMI 2021 Annual Meeting","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Kentaro, Tamura"}],"nameIdentifiers":[{"nameIdentifier":"994308","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii"}],"nameIdentifiers":[{"nameIdentifier":"994309","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kana, Yamazaki"}],"nameIdentifiers":[{"nameIdentifier":"994310","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoyoshi, Yamamoto"}],"nameIdentifiers":[{"nameIdentifier":"994311","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Higashi"}],"nameIdentifiers":[{"nameIdentifier":"994312","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Tsuji"}],"nameIdentifiers":[{"nameIdentifier":"994313","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kentaro, Tamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994314","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ryuichi, Nishii","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994315","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kana, Yamazaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994316","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Naoyoshi, Yamamoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994317","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuya, Higashi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994318","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hiroshi, Tsuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"994319","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Metabolic Tumor Volume of Methionine PET in Early Lung Cancer is Useful for Predicting Prognosis of Patients treated with Carbon Ion Radiotherapy","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Metabolic Tumor Volume of Methionine PET in Early Lung Cancer is Useful for Predicting Prognosis of Patients treated with Carbon Ion Radiotherapy"}]},"item_type_id":"10005","owner":"1","path":["28"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-06-04"},"publish_date":"2021-06-04","publish_status":"0","recid":"82932","relation_version_is_last":true,"title":["Metabolic Tumor Volume of Methionine PET in Early Lung Cancer is Useful for Predicting Prognosis of Patients treated with Carbon Ion Radiotherapy"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T20:06:17.390424+00:00"}