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  1. 原著論文

Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix.

https://repo.qst.go.jp/records/82916
https://repo.qst.go.jp/records/82916
81d32c07-bb67-486b-a169-528c174bba3e
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-06-03
タイトル
タイトル Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix.
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Okonogi, Noriyuki

× Okonogi, Noriyuki

WEKO 1024464

Okonogi, Noriyuki

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Ando, Ken

× Ando, Ken

WEKO 1024465

Ando, Ken

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Murata, Kazutoshi

× Murata, Kazutoshi

WEKO 1024466

Murata, Kazutoshi

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Wakatsuki, Masaru

× Wakatsuki, Masaru

WEKO 1024467

Wakatsuki, Masaru

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Shin-Ei, Noda

× Shin-Ei, Noda

WEKO 1024468

Shin-Ei, Noda

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Irie, Daisuke

× Irie, Daisuke

WEKO 1024469

Irie, Daisuke

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Tsuji, Hiroshi

× Tsuji, Hiroshi

WEKO 1024470

Tsuji, Hiroshi

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Shozu, Makio

× Shozu, Makio

WEKO 1024471

Shozu, Makio

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Ohno, Tatsuya

× Ohno, Tatsuya

WEKO 1024472

Ohno, Tatsuya

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Noriyuki, Okonogi

× Noriyuki, Okonogi

WEKO 1024473

en Noriyuki, Okonogi

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Ken, Ando

× Ken, Ando

WEKO 1024474

en Ken, Ando

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Kazutoshi, Murata

× Kazutoshi, Murata

WEKO 1024475

en Kazutoshi, Murata

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Masaru, Wakatsuki

× Masaru, Wakatsuki

WEKO 1024476

en Masaru, Wakatsuki

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Daisuke, Irie

× Daisuke, Irie

WEKO 1024477

en Daisuke, Irie

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Hiroshi, Tsuji

× Hiroshi, Tsuji

WEKO 1024478

en Hiroshi, Tsuji

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Tatsuya, Ohno

× Tatsuya, Ohno

WEKO 1024479

en Tatsuya, Ohno

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抄録
内容記述タイプ Abstract
内容記述 The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB-IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.
書誌情報 Cancers

巻 13, 号 11, p. 2713, 発行日 2021-05
出版者
出版者 MDPI
ISSN
収録物識別子タイプ ISSN
収録物識別子 2072-6694
PubMed番号
識別子タイプ PMID
関連識別子 34072676
DOI
識別子タイプ DOI
関連識別子 10.3390/cancers13112713
関連サイト
識別子タイプ URI
関連識別子 https://www.mdpi.com/2072-6694/13/11/2713
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