@article{oai:repo.qst.go.jp:00082916,
 author = {Okonogi, Noriyuki and Ando, Ken and Murata, Kazutoshi and Wakatsuki, Masaru and Shin-Ei, Noda and Irie, Daisuke and Tsuji, Hiroshi and Shozu, Makio and Ohno, Tatsuya and Noriyuki, Okonogi and Ken, Ando and Kazutoshi, Murata and Masaru, Wakatsuki and Daisuke, Irie and Hiroshi, Tsuji and Tatsuya, Ohno},
 issue = {11},
 journal = {Cancers},
 month = {May},
 note = {The clinical significance of carbon-ion radiotherapy (CIRT) for adenocarcinoma (AC) of the uterine cervix has been assessed in several single-institutional studies. To validate the significance, we conducted a multi-institutional survey of CIRT for locally advanced AC (LAAC) of the uterine cervix. We retrospectively analyzed the clinical outcomes of patients with stage IIB-IVA LAAC of the uterine cervix who underwent chemo-CIRT or CIRT alone between April 2010 and April 2016. Patients received 74.4 Gy (relative biological effectiveness [RBE]) in 20 fractions of CIRT or 55.2 Gy (RBE) in 16 fractions of CIRT plus three sessions of brachytherapy. Patients aged ≤ 70 years with adequate bone marrow and organ function were administered cisplatin weekly (40 mg/m per week for up to 5 weeks). Fifty-five patients were enrolled in this study. The median follow-up period was 67.5 months. The 5-year overall survival (OS) and local control (LC) rates were 68.6% and 65.2%, respectively. Multivariate analysis showed that the initial tumor response within 6 months was significantly associated with LC and OS. The present study represents promising outcomes of CIRT or chemo-CIRT for LAAC of the uterine cervix, especially in the cases showing initial rapid regression of the tumor.},
 title = {Multi-Institutional Retrospective Analysis of Carbon-Ion Radiotherapy for Patients with Locally Advanced Adenocarcinoma of the Uterine Cervix.},
 volume = {13},
 year = {2021}
}