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Associations of tau aggregates and oxidative stress to apathy levels in progressive supranuclear palsy
https://repo.qst.go.jp/records/82844
https://repo.qst.go.jp/records/828444e25dc49-e656-43a8-bcb0-bcbb13d39a76
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-05-19 | |||||
| タイトル | ||||||
| タイトル | Associations of tau aggregates and oxidative stress to apathy levels in progressive supranuclear palsy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kiwamu, Matsuoka
× Kiwamu, Matsuoka× Yuhei, Takado× Kenji, Tagai× Manabu, Kubota× Yasunori, Sano× Keisuke, Takahata× Maiko, Ono× Chie, Seki× Hideki, Matsumoto× Hironobu, Endo× Hitoshi, Shinoto× Near, Jamie× Kazunori, Kawamura× Zhang, Ming-Rong× Hitoshi, Shimada× Makoto, Higuchi× Kiwamu, Matsuoka× Yuhei, Takado× Kenji, Tagai× Manabu, Kubota× Yasunori, Sano× Keisuke, Takahata× Maiko, Ono× Chie, Seki× Hideki, Matsumoto× Hironobu, Endo× Hitoshi, Shinoto× Kazunori, Kawamura× Zhang, Ming-Rong× Hitoshi, Shimada× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Apathy is characterized by lack of motivation. We investigated the mechanisms underlying apathy in progressive supranuclear palsy (PSP), which is characterized by tau aggregate accumulations causing oxidative stress in the brain. Using magnetic resonance spectroscopy and tau positron emission tomography, we found associations of apathy levels with glutathione levels in the posterior cingulate cortex (PCC), tau aggregate accumulation levels in the angular gyrus/PCC, and atrophy of the right inferior frontal gyrus and anterior cingulate cortex. The vulnerability of the anterior and posterior brain regions where apathy is related is suggested as possible underlying mechanisms for apathy in PSP. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 2021 Annual Meeting & Exhibition - ISMRM | |||||
| 発表年月日 | ||||||
| 日付 | 2021-05-18 | |||||
| 日付タイプ | Issued | |||||
