@misc{oai:repo.qst.go.jp:00082844, author = {Kiwamu, Matsuoka and Yuhei, Takado and Kenji, Tagai and Manabu, Kubota and Yasunori, Sano and Keisuke, Takahata and Maiko, Ono and Chie, Seki and Hideki, Matsumoto and Hironobu, Endo and Hitoshi, Shinoto and Near, Jamie and Kazunori, Kawamura and Zhang, Ming-Rong and Hitoshi, Shimada and Makoto, Higuchi and Kiwamu, Matsuoka and Yuhei, Takado and Kenji, Tagai and Manabu, Kubota and Yasunori, Sano and Keisuke, Takahata and Maiko, Ono and Chie, Seki and Hideki, Matsumoto and Hironobu, Endo and Hitoshi, Shinoto and Kazunori, Kawamura and Zhang, Ming-Rong and Hitoshi, Shimada and Makoto, Higuchi}, month = {May}, note = {Apathy is characterized by lack of motivation. We investigated the mechanisms underlying apathy in progressive supranuclear palsy (PSP), which is characterized by tau aggregate accumulations causing oxidative stress in the brain. Using magnetic resonance spectroscopy and tau positron emission tomography, we found associations of apathy levels with glutathione levels in the posterior cingulate cortex (PCC), tau aggregate accumulation levels in the angular gyrus/PCC, and atrophy of the right inferior frontal gyrus and anterior cingulate cortex. The vulnerability of the anterior and posterior brain regions where apathy is related is suggested as possible underlying mechanisms for apathy in PSP., 2021 Annual Meeting & Exhibition - ISMRM}, title = {Associations of tau aggregates and oxidative stress to apathy levels in progressive supranuclear palsy}, year = {2021} }