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Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl42- complex
https://repo.qst.go.jp/records/82772
https://repo.qst.go.jp/records/82772c3a3e5df-754c-4912-a03c-6850ae9f7ca9
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-25 | |||||
| タイトル | ||||||
| タイトル | Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl42- complex | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Honoka, Obata
× Honoka, Obata× Katsuyuki, Minegishi× Kotaro, Nagatsu× Mikako, Ogawa× Zhang, Ming-Rong× Honoka, Obata× Katsuyuki, Minegishi× Kotaro, Nagatsu× Mikako, Ogawa× Zhang, Ming-Rong |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtⅡCl42- from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[PtⅡCl2(NH3)2] ([*Pt]cisplatin) from [*Pt]PtⅡCl42-. [*Pt]PtⅡCl42- was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of IrⅣCl62- with ascorbic acid. The ligand-substitution reaction of Cl with NH3 was promoted by treating n.c.a. [*Pt]PtⅡCl42- with excess NH3 and heating the reaction mixture, and n.c.a. [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99+% at the end of synthesis (EOS). | |||||
| 書誌情報 |
Scientific Reports 巻 11, p. 8140, 発行日 2021-04 |
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| 出版者 | ||||||
| 出版者 | Springer | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-021-87576-2 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-021-87576-2 | |||||
