@article{oai:repo.qst.go.jp:00082772,
 author = {Honoka, Obata and Katsuyuki, Minegishi and Kotaro, Nagatsu and Mikako, Ogawa and Zhang, Ming-Rong and Honoka, Obata and Katsuyuki, Minegishi and Kotaro, Nagatsu and Mikako, Ogawa and Zhang, Ming-Rong},
 journal = {Scientific Reports},
 month = {Apr},
 note = {We developed a novel method for production of no-carrier-added (n.c.a.) [188, 189, 191Pt]PtⅡCl42- from an Ir target material, and then synthesized n.c.a. [*Pt]cis-[PtⅡCl2(NH3)2] ([*Pt]cisplatin) from [*Pt]PtⅡCl42-. [*Pt]PtⅡCl42- was prepared as a synthetic precursor of n.c.a. *Pt complex by a combination of resin extraction and anion-exchange chromatography after the selective reduction of IrⅣCl62- with ascorbic acid. The ligand-substitution reaction of Cl with NH3 was promoted by treating n.c.a. [*Pt]PtⅡCl42- with excess NH3 and heating the reaction mixture, and n.c.a. [*Pt]cisplatin was successfully produced without employing precipitation routes. After this treatment, [*Pt]cisplatin was isolated through preparative HPLC with a radiochemical purity of 99+% at the end of synthesis (EOS).},
 title = {Synthesis of no-carrier-added [188, 189, 191Pt]cisplatin from a cyclotron produced 188, 189, 191PtCl42- complex},
 volume = {11},
 year = {2021}
}