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Analysis of radiotherapy‑induced alteration of CD8+ T cells and PD‑L1 expression in patients with uterine cervical squamous cell carcinoma
https://repo.qst.go.jp/records/82762
https://repo.qst.go.jp/records/827626f8aefca-91e8-44b0-8bf1-bcdf29f6b3e0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-04-01 | |||||
| タイトル | ||||||
| タイトル | Analysis of radiotherapy‑induced alteration of CD8+ T cells and PD‑L1 expression in patients with uterine cervical squamous cell carcinoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
MORI, YASUMASA
× MORI, YASUMASA× SATO, HIRO× KUMAZAWA, TAKUYA× BUNGA MAYANG PERMATA, TIARA× Yuya, Yoshimoto× Kazutoshi, Murata× SHIN‑EI, NODA× Kaminuma, Takuya× Ken, Ando× OIKE, TAKAHIRO× Noriyuki, Okonogi× Kohei, Okada× KAKOTI, SANGEETA× Keiji, Suzuki× IKOTA, HAYATO× YOKOO, HIDEAKI× Takashi, Nakano× Tatsuya, Ohno× Atsushi, Shibata× Yuya, Yoshimoto× Kazutoshi, Murata× Kaminuma, Takuya× Ken, Ando× Noriyuki, Okonogi× Kohei, Okada× Keiji, Suzuki× Takashi, Nakano× Tatsuya, Ohno× Atsushi, Shibata |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Abstract. Radiotherapy induces an immune response in the cancer microenvironment that may influence clinical outcome. The present study aimed to analyse the alteration of CD8+ T‑cell infiltration and programmed death‑ligand 1 (PD‑L1) expression following radiotherapy in clinical samples from patients with uterine cervical squamous cell carcinoma. Additionally, the current study sought to analyse the association between these immune responses and clinical outcomes. A total of 75 patients who received either definitive chemoradiotherapy or radiotherapy were retrospectively analyzed. CD8+ T‑cell infiltration and PD‑L1 expression were determined by immunohistochemistry using biopsy specimens before radiotherapy (pre‑RT) and after 10 Gy radiotherapy (post‑10 Gy). The PD‑L1+ rate was significantly increased from 5% (4/75) pre‑RT to 52% (39/75) post‑10 Gy (P<0.01). Despite this increase in the PD‑L1+ rate post‑10 Gy, there was no significant association between both pre‑RT and post‑10 Gy and overall survival (OS), locoregional control (LC) and progression‑free survival (PFS). On the other hand, the CD8+ T‑cell infiltration density was significantly decreased for all patients (median, 23.1% pre‑RT vs. 16.9% post‑10 Gy; P=0.038); however, this tended to increase in patients treated with radiotherapy alone (median, 17.7% pre‑RT vs. 24.0% post‑10 Gy; P=0.400). Notably, patients with high CD8+ T‑cell infiltration either pre‑RT or post‑10 Gy exhibited positive associations with OS, LC and PFS. Thus, the present analysis suggested that CD8+ T‑cell infiltration may be a prognostic biomarker for patients with cervical cancer receiving radiotherapy. Furthermore, immune checkpoint inhibitors may be effective in patients who have received radiotherapy, since radiotherapy upregulated PD‑L1 expression in cervical cancer specimens. | |||||
| 書誌情報 |
ONCOLOGY LETTERS 巻 21, 号 6, p. 466, 発行日 2021-04 |
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| 出版者 | ||||||
| 出版者 | SPANDIDOS PUBLICATIONS | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1792-1074 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33868484 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3892/ol.2021.12707 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.spandidos-publications.com/10.3892/ol.2021.12707 | |||||
