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  1. 原著論文

Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells

https://repo.qst.go.jp/records/82094
https://repo.qst.go.jp/records/82094
993c9a88-62d4-47e2-a612-d3f2f9370a0a
Item type 学術雑誌論文 / Journal Article(1)
公開日 2021-03-09
タイトル
タイトル Impact of hypoxia on the double-strand break repair after photon and carbon ion irradiation of radioresistant HNSCC cells
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Anne‑SophieWozny

× Anne‑SophieWozny

WEKO 1006985

Anne‑SophieWozny

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Alphonse, Gersende

× Alphonse, Gersende

WEKO 1006986

Alphonse, Gersende

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Cassard, Audrey

× Cassard, Audrey

WEKO 1006987

Cassard, Audrey

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Céline, Malésys

× Céline, Malésys

WEKO 1006988

Céline, Malésys

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Louati, Safa

× Louati, Safa

WEKO 1006989

Louati, Safa

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Beuve, Michael

× Beuve, Michael

WEKO 1006990

Beuve, Michael

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Lalle, Philippe

× Lalle, Philippe

WEKO 1006991

Lalle, Philippe

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Ardail, Dominique

× Ardail, Dominique

WEKO 1006992

Ardail, Dominique

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Nakajima, Tetsuo

× Nakajima, Tetsuo

WEKO 1006993

Nakajima, Tetsuo

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Claire, Rodriguez‑Lafrasse

× Claire, Rodriguez‑Lafrasse

WEKO 1006994

Claire, Rodriguez‑Lafrasse

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Tetsuo, Nakajima

× Tetsuo, Nakajima

WEKO 1006995

en Tetsuo, Nakajima

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抄録
内容記述タイプ Abstract
内容記述 DNA double-strand breaks (DSBs) induced by photon irradiation are the most deleterious damage for cancer cells and their efficient repair may contribute to radioresistance, particularly in hypoxic conditions. Carbon ions (C-ions) act independently of the oxygen concentration and trigger complex- and clustered-DSBs difficult to repair. Understanding the interrelation between hypoxia, radiation-type, and DNA-repair is therefore essential for overcoming radioresistance. The DSBs signaling and the contribution of the canonical non-homologous end-joining (NHEJ-c) and homologous-recombination (HR) repair pathways were assessed by immunostaining in two cancer-stem-cell (CSCs) and non-CSCs HNSCC cell lines. Detection and signaling of DSBs were lower in response to C-ions than photons. Hypoxia increased the decay-rate of the detected DSBs (γH2AX) in CSCs after photons and the initiation of DSB repair signaling (P-ATM) in CSCs and non-CSCs after both radiations, but not the choice of DSB repair pathway (53BP1). Additionally, hypoxia increased the NHEJ-c (DNA-PK) and the HR pathway (RAD51) activation only after photons. Furthermore, the involvement of the HR seemed to be higher in CSCs after photons and in non-CSCs after C-ions. Taken together, our results show that C-ions may overcome the radioresistance of HNSCC associated with DNA repair, particularly in CSCs, and independently of a hypoxic microenvironment.
書誌情報 Scientific Reports

巻 10, p. 21357, 発行日 2020-12
ISSN
収録物識別子タイプ ISSN
収録物識別子 2045-2322
DOI
識別子タイプ DOI
関連識別子 10.1038/s41598-020-78354-7
関連サイト
識別子タイプ URI
関連識別子 https://www.nature.com/articles/s41598-020-78354-7
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