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How COVID-19 induces cytokine storm with high mortality
https://repo.qst.go.jp/records/82077
https://repo.qst.go.jp/records/8207705b6cd3e-ccac-494e-ac9d-2ea5524c694a
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-03-09 | |||||
| タイトル | ||||||
| タイトル | How COVID-19 induces cytokine storm with high mortality | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Hojyo, Shintaro
× Hojyo, Shintaro× Uchida, Mona× Kumiko Tanaka× Hasebe, Rie× Tanaka, Yuki× Murakami, Masaaki× Toshio, Hirano× Toshio, Hirano |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some COVID-19 patients encounter a severe symptom of acute respiratory distress syndrome (ARDS) with high mortality. This high severity is dependent on a cytokine storm, most likely induced by the interleukin-6 (IL-6) amplifier, which is hyper-activation machinery that regulates the nuclear factor kappa B (NF-κB) pathway and stimulated by the simultaneous activation of IL-6-signal transducer and activator of transcription 3 (STAT3) and NF-κB signaling in non-immune cells including alveolar epithelial cells and endothelial cells. We hypothesize that IL-6-STAT3 signaling is a promising therapeutic target for the cytokine storm in COVID-19, because IL-6 is a major STAT3 stimulator, particularly during inflammation. We herein review the pathogenic mechanism and potential therapeutic targets of ARDS in COVID-19 patients. | |||||
| 書誌情報 |
Inflammation and Regeneration 巻 40, p. 37, 発行日 2020-10 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1880-8190 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1186/s41232-020-00146-3 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://inflammregen.biomedcentral.com/articles/10.1186/s41232-020-00146-3 | |||||
