{"created":"2023-05-15T15:00:28.767345+00:00","id":82077,"links":{},"metadata":{"_buckets":{"deposit":"db534bb0-77c5-46d1-89d1-eec0ce35c308"},"_deposit":{"created_by":1,"id":"82077","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"82077"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00082077","sets":["1"]},"author_link":["1011414","1011416","1011415","1011417","1011419","1011418","1011413","1011412"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-10","bibliographicIssueDateType":"Issued"},"bibliographicPageStart":"37","bibliographicVolumeNumber":"40","bibliographic_titles":[{"bibliographic_title":"Inflammation and Regeneration"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The newly emerging coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was first reported in Wuhan, China, but has rapidly spread all over the world. Some COVID-19 patients encounter a severe symptom of acute respiratory distress syndrome (ARDS) with high mortality. This high severity is dependent on a cytokine storm, most likely induced by the interleukin-6 (IL-6) amplifier, which is hyper-activation machinery that regulates the nuclear factor kappa B (NF-κB) pathway and stimulated by the simultaneous activation of IL-6-signal transducer and activator of transcription 3 (STAT3) and NF-κB signaling in non-immune cells including alveolar epithelial cells and endothelial cells. We hypothesize that IL-6-STAT3 signaling is a promising therapeutic target for the cytokine storm in COVID-19, because IL-6 is a major STAT3 stimulator, particularly during inflammation. We herein review the pathogenic mechanism and potential therapeutic targets of ARDS in COVID-19 patients.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1186/s41232-020-00146-3","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://inflammregen.biomedcentral.com/articles/10.1186/s41232-020-00146-3","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1880-8190","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Hojyo, Shintaro"}],"nameIdentifiers":[{"nameIdentifier":"1011412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchida, Mona"}],"nameIdentifiers":[{"nameIdentifier":"1011413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kumiko Tanaka"}],"nameIdentifiers":[{"nameIdentifier":"1011414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hasebe, Rie"}],"nameIdentifiers":[{"nameIdentifier":"1011415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tanaka, Yuki"}],"nameIdentifiers":[{"nameIdentifier":"1011416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Murakami, Masaaki"}],"nameIdentifiers":[{"nameIdentifier":"1011417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshio, Hirano"}],"nameIdentifiers":[{"nameIdentifier":"1011418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toshio, Hirano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011419","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"How COVID-19 induces cytokine storm with high mortality","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"How COVID-19 induces cytokine storm with high mortality"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-03-09"},"publish_date":"2021-03-09","publish_status":"0","recid":"82077","relation_version_is_last":true,"title":["How COVID-19 induces cytokine storm with high mortality"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T19:00:12.554085+00:00"}