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Carbon ion radiotherapy for sacral chordoma: A retrospective nationwide multicentre study in Japan
https://repo.qst.go.jp/records/81785
https://repo.qst.go.jp/records/817857f817c20-12ed-48eb-b931-710456e247c0
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-02-05 | |||||
| タイトル | ||||||
| タイトル | Carbon ion radiotherapy for sacral chordoma: A retrospective nationwide multicentre study in Japan | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Demizu, Yusuke
× Demizu, Yusuke× Reiko, Imai× Hiroki, Kiyohara× Akira, Matsunobu× Masahiko, Okamoto× Tomoaki, Okimoto× Hiroshi, Tsuji× Tatsuya, Ohno× Yoshiyuki, Shioyama× Kenji, Nemoto× Takashi, Nakano× Tadashi, Kamada× Reiko, Imai× Hiroki, Kiyohara× Akira, Matsunobu× Masahiko, Okamoto× Tomoaki, Okimoto× Hiroshi, Tsuji× Tatsuya, Ohno× Yoshiyuki, Shioyama× Kenji, Nemoto× Takashi, Nakano× Tadashi, Kamada |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background and purpose: Usefulness of carbon ion radiotherapy (CIRT) for sacral chordoma has been reported from single institutions. We conducted a retrospective nationwide multicentre study to evaluate the clinical outcomes of CIRT for sacral chordoma in Japan. Materials and methods: A total of 219 patients who underwent CIRT for sacral chordoma at institutions across Japan between December 2003 and July 2014 were included in this study. Results: Median patient age was 67 years (range, 26-87 years). Most patients had no history of surgical resection (96%). The most frequent planning target volume (PTV) range was 100-500 mL (65%). The most frequently used dose-fractionation was 67.2 Gy (relative biological effectiveness) in 16 fractions (65%). The median follow-up was 56 months (range, 7-132 months). The 5-year overall survival (OS), progression-free survival, and local control rates were 84%, 48%, and 72%, respectively. Frequent sites of out-of-field recurrence included bone (9%) and lung (9%) metastases. The Cox proportional hazards model revealed that both younger age (P = 0.004) and smaller PTV (P = 0.001) were associated with significantly better OS. Acute toxicities of ≥Grade 3 occurred in eight patients (4%). Late toxicities of ≥Grade 3 occurred in 13 patients (6%): skin disorders in six patients (3%), pain in three (1%), myositis in three (1%), etc. CONCLUSION: Our retrospective nationwide multicentre study showed that CIRT for sacral chordoma was effective and safe, and replicated the previously reported data from a representative CIRT institution in Japan demonstrating high local control and low toxicity rates. |
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| 書誌情報 |
Radiotherapy and oncology 巻 154, p. 1-5, 発行日 2020-09 |
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| 出版者 | ||||||
| 出版者 | Elsevier | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0167-8140 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32941958 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.radonc.2020.09.018 | |||||
| 関連サイト | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | https://doi.org/10.1016/j.radonc.2020.09.018 | |||||
