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Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes
https://repo.qst.go.jp/records/81625
https://repo.qst.go.jp/records/81625fa36d6e3-188d-4195-86dc-3dd933492d01
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-16 | |||||
| タイトル | ||||||
| タイトル | Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Moriyama, Hitomi
× Moriyama, Hitomi× Daino, Kazuhiro× Ishikawa, Atsuko× Imaoka, Tatsuhiko× Nishimura, Mayumi× Nishimura, Yukiko× Takabatake, Masaru× Morioka, Takamitsu× Inoue, Kazumasa× Fukushi, Masahiro× Shimada, Yoshiya× Kakinuma, Shizuko× Hitomi, Moriyama× Kazuhiro, Daino× Atsuko, Ishikawa× Tatsuhiko, Imaoka× Mayumi, Nishimura× Yukiko, Nishimura× Masaru, Takabatake× Takamitsu, Morioka× Yoshiya, Shimada× Shizuko, Kakinuma |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background/Aim: Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics of mammary carcinomas induced by neutrons. Materials and Methods: Mammary carcinomas obtained from female Sprague-Dawley rats irradiated at 7 weeks of age with 0.97 Gy neutrons or 4 Gy γ-rays and from non-irradiated rats were classified into luminal and non-luminal subtypes by immunohistochemistry. Their mutational landscapes were determined by whole-exome sequencing. Results: Neutrons significantly raised the incidence of luminal mammary carcinomas over the non-luminal subtype. Somatic mutations were identified in cancer genes involved in several signalling pathways, including Keap1/Nrf2, Pi3k/Akt and Wnt/β-catenin. Focal copy-number losses involving cancer genes were observed mainly in carcinomas from the irradiated rats. Conclusion: Neutrons increase the incidence of luminal mammary carcinomas, probably through gene mutations similar to those found in human breast cancers, and focal copy-number losses including cancer genes that are characteristics of radiation-induced mammary carcinomas. |
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| 書誌情報 |
Anticancer Research 巻 41, 号 1, p. 55-70, 発行日 2021-01 |
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| 出版者 | ||||||
| 出版者 | International Institute of Anticancer Research (IIAR) | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0250-7005 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 33419799 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.21873/anticanres.14751 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://ar.iiarjournals.org/content/41/1/55 | |||||
