{"created":"2023-05-15T15:00:08.840130+00:00","id":81625,"links":{},"metadata":{"_buckets":{"deposit":"29619f23-4765-486e-9293-5728f194b7a2"},"_deposit":{"created_by":1,"id":"81625","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81625"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081625","sets":["1"]},"author_link":["1016415","1016412","1016424","1016413","1016431","1016427","1016422","1016426","1016411","1016417","1016423","1016428","1016430","1016419","1016425","1016410","1016429","1016416","1016414","1016421","1016420","1016418"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageEnd":"70","bibliographicPageStart":"55","bibliographicVolumeNumber":"41","bibliographic_titles":[{"bibliographic_title":"Anticancer Research"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Background/Aim: Our understanding of cancer risk from neutron exposure is limited. We aimed to reveal the characteristics of mammary carcinomas induced by neutrons.\nMaterials and Methods: Mammary carcinomas obtained from female Sprague-Dawley rats irradiated at 7 weeks of age with 0.97 Gy neutrons or 4 Gy γ-rays and from non-irradiated rats were classified into luminal and non-luminal subtypes by immunohistochemistry. Their mutational landscapes were determined by whole-exome sequencing.\nResults: Neutrons significantly raised the incidence of luminal mammary carcinomas over the non-luminal subtype. Somatic mutations were identified in cancer genes involved in several signalling pathways, including Keap1/Nrf2, Pi3k/Akt and Wnt/β-catenin. Focal copy-number losses involving cancer genes were observed mainly in carcinomas from the irradiated rats.\nConclusion: Neutrons increase the incidence of luminal mammary carcinomas, probably through gene mutations similar to those found in human breast cancers, and focal copy-number losses including cancer genes that are characteristics of radiation-induced mammary carcinomas.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"International Institute of Anticancer Research (IIAR)"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"33419799","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.21873/anticanres.14751","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://ar.iiarjournals.org/content/41/1/55","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"0250-7005","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Moriyama, Hitomi"}],"nameIdentifiers":[{"nameIdentifier":"1016410","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Daino, Kazuhiro"}],"nameIdentifiers":[{"nameIdentifier":"1016411","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishikawa, Atsuko"}],"nameIdentifiers":[{"nameIdentifier":"1016412","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Imaoka, Tatsuhiko"}],"nameIdentifiers":[{"nameIdentifier":"1016413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Mayumi"}],"nameIdentifiers":[{"nameIdentifier":"1016414","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishimura, Yukiko"}],"nameIdentifiers":[{"nameIdentifier":"1016415","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takabatake, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"1016416","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Morioka, Takamitsu"}],"nameIdentifiers":[{"nameIdentifier":"1016417","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Inoue, Kazumasa"}],"nameIdentifiers":[{"nameIdentifier":"1016418","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Fukushi, Masahiro"}],"nameIdentifiers":[{"nameIdentifier":"1016419","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shimada, Yoshiya"}],"nameIdentifiers":[{"nameIdentifier":"1016420","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kakinuma, Shizuko"}],"nameIdentifiers":[{"nameIdentifier":"1016421","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitomi, Moriyama","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016422","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazuhiro, Daino","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016423","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Atsuko, Ishikawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016424","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tatsuhiko, Imaoka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016425","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mayumi, Nishimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016426","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yukiko, Nishimura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016427","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Masaru, Takabatake","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016428","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takamitsu, Morioka","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016429","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshiya, Shimada","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016430","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shizuko, Kakinuma","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1016431","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-16"},"publish_date":"2020-11-16","publish_status":"0","recid":"81625","relation_version_is_last":true,"title":["Exome of Radiation-induced Rat Mammary Carcinoma Shows Copy-number Losses and Mutations in Human-relevant Cancer Genes"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:40:27.765884+00:00"}