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A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition
https://repo.qst.go.jp/records/81623
https://repo.qst.go.jp/records/81623761a1a06-b0f9-4bc1-ac80-1b7b81e7ad03
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2021-01-11 | |||||
| タイトル | ||||||
| タイトル | A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Pecori, Federico
× Pecori, Federico× Yokota, Ikuko× Hanamatsu, Hisatoshi× Miura, Taichi× Ogura, Chika× Ota, Hayato× Jun‑ichi, Furukawa× Oki, Shinya× Yamamoto, Kazuo× Yoshie, Osamu× Nishihara, Shoko× Taichi, Miura× Chika, Ogura× Hayato, Ota× Shoko, Nishihara |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and EpiLCs, revealing that overall glycosylation undergoes dramatic changes from early stages of development. Remarkably, we showed for the first time the presence of a developmentally regulated network orchestrating glycosylation changes and identified polycomb repressive complex 2 (PRC2) as a key component involved in this process. Collectively, our findings provide novel insights into the naïve-to-primed pluripotent state transition and advance the understanding of glycosylation complex regulation during early mouse embryonic development. | |||||
| 書誌情報 |
Scientific Reports 巻 11, 号 1, p. 1276, 発行日 2021-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-020-79666-4 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-020-79666-4 | |||||
