{"created":"2023-05-15T15:00:08.751916+00:00","id":81623,"links":{},"metadata":{"_buckets":{"deposit":"38273646-abcb-4709-b135-85dfd1de6516"},"_deposit":{"created_by":1,"id":"81623","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81623"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081623","sets":["1"]},"author_link":["1012105","1012114","1012104","1012112","1012113","1012111","1012116","1012109","1012106","1012107","1012117","1012108","1012110","1012103","1012115"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"1","bibliographicPageStart":"1276","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"Scientific Reports"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Embryonic stem cells (ESCs) and epiblast-like cells (EpiLCs) recapitulate in vitro the epiblast first cell lineage decision, allowing characterization of the molecular mechanisms underlying pluripotent state transition. Here, we performed a comprehensive and comparative analysis of total glycomes of mouse ESCs and EpiLCs, revealing that overall glycosylation undergoes dramatic changes from early stages of development. Remarkably, we showed for the first time the presence of a developmentally regulated network orchestrating glycosylation changes and identified polycomb repressive complex 2 (PRC2) as a key component involved in this process. Collectively, our findings provide novel insights into the naïve-to-primed pluripotent state transition and advance the understanding of glycosylation complex regulation during early mouse embryonic development.","subitem_description_type":"Abstract"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41598-020-79666-4","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41598-020-79666-4","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"2045-2322","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Pecori, Federico"}],"nameIdentifiers":[{"nameIdentifier":"1012103","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yokota, Ikuko"}],"nameIdentifiers":[{"nameIdentifier":"1012104","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hanamatsu, Hisatoshi"}],"nameIdentifiers":[{"nameIdentifier":"1012105","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Miura, Taichi"}],"nameIdentifiers":[{"nameIdentifier":"1012106","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ogura, Chika"}],"nameIdentifiers":[{"nameIdentifier":"1012107","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ota, Hayato"}],"nameIdentifiers":[{"nameIdentifier":"1012108","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jun‑ichi, Furukawa"}],"nameIdentifiers":[{"nameIdentifier":"1012109","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oki, Shinya"}],"nameIdentifiers":[{"nameIdentifier":"1012110","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamamoto, Kazuo"}],"nameIdentifiers":[{"nameIdentifier":"1012111","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yoshie, Osamu"}],"nameIdentifiers":[{"nameIdentifier":"1012112","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nishihara, Shoko"}],"nameIdentifiers":[{"nameIdentifier":"1012113","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taichi, Miura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012114","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Chika, Ogura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012115","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hayato, Ota","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012116","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shoko, Nishihara","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1012117","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2021-01-11"},"publish_date":"2021-01-11","publish_status":"0","recid":"81623","relation_version_is_last":true,"title":["A defined glycosylation regulatory network modulates total glycome dynamics during pluripotency state transition"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:57:10.545459+00:00"}