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The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy
https://repo.qst.go.jp/records/81181
https://repo.qst.go.jp/records/81181371332c6-7114-40f3-8a4e-c9d672624b3d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-12-03 | |||||
| タイトル | ||||||
| タイトル | The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ishikawa, Hitoshi
× Ishikawa, Hitoshi× Keiko Higuchi× Kaminuma, Takuya× Takezawa, Yutaka× Saito, Yoshitaka× Toru Etsunaga× Kazushi Maruo× Kawamura, Hidemasa× Kubo, Nobuteru× Nakano, Takashi× Mikio Kobayashi× Hitoshi, Ishikawa× Kaminuma, Takuya× Hidemasa, Kawamura× Nobuteru, Kubo× Takashi, Nakano |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The feasibility and efficacy of hypofractionated salvage radiotherapy (HS-RT) for prostate cancer (PC) with biochemical recurrence (BR) after prostatectomy, and the usefulness of prostate-specific antigen (PSA) kinetics as a predictor of BR, were evaluated in 38 patients who received HS-RT without androgen deprivation therapy between May 2009 and January 2017. Their median age, PSA level and PSA doubling time (PSA-DT) at the start of HS-RT were 68 (53–74) years, 0.28 (0.20–0.79) ng/ml and 7.7 (2.3–38.5) months, respectively. A total dose of 60 Gy in 20 fractions (three times a week) was three-dimensionally delivered to the prostate bed. After a median follow-up of 62 (30–100) months, 19 (50%) patients developed a second BR after HS-RT, but only 1 patient died before the last follow-up. The 5-year overall survival and BR-free survival rates were 97.1 and 47.4%, respectively. Late grade 2 gastrointestinal and genitourinary morbidities were observed in 0 and 5 (13%) patients, respectively. The PSA level as well as pathological T-stage and surgical margin status were regarded as significant predictive factors for a second BR by multivariate analysis. BR developed within 6 months after HS-RT in 11 (85%) of 13 patients with a PSADT < 10 months compared with 1 (17%) of 6 with a PSA-DT ≥ 10 months (median time to BR: 3 vs 14 months, P < 0.05). Despite the small number of patients, our HS-RT protocol seems feasible, and PSA kinetics may be useful for predicting the risk of BR and determining the appropriate follow-up schedule. |
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| 書誌情報 |
Journal of Radiation Research 巻 61, 号 6, p. 908-919, 発行日 2020-12 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1349-9157 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32888035 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/jrr/rraa074 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/jrr/article/61/6/908/5901560 | |||||
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Ishikawa, Hitoshi, Keiko Higuchi, Kaminuma, Takuya, Takezawa, Yutaka, Saito, Yoshitaka, Toru Etsunaga, Kazushi Maruo, Kawamura, Hidemasa, Kubo, Nobuteru, Nakano, Takashi, Mikio Kobayashi, Hitoshi, Ishikawa, Kaminuma, Takuya, Hidemasa, Kawamura, Nobuteru, Kubo, Takashi, Nakano, 2020, The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy : Oxford University Press, 908–919 p.
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