{"created":"2023-05-15T14:59:49.463464+00:00","id":81181,"links":{},"metadata":{"_buckets":{"deposit":"2106befd-448e-4aee-bcec-c3cbba5ad16c"},"_deposit":{"created_by":1,"id":"81181","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81181"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081181","sets":["1"]},"author_link":["1011732","1011736","1011733","1011742","1011739","1011735","1011741","1011731","1011730","1011740","1011737","1011743","1011745","1011738","1011744","1011734"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"6","bibliographicPageEnd":"919","bibliographicPageStart":"908","bibliographicVolumeNumber":"61","bibliographic_titles":[{"bibliographic_title":"Journal of Radiation Research　"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"The feasibility and efficacy of hypofractionated salvage radiotherapy (HS-RT) for prostate cancer (PC) with biochemical recurrence (BR) after prostatectomy, and the usefulness of prostate-specific antigen (PSA) kinetics as a\npredictor of BR, were evaluated in 38 patients who received HS-RT without androgen deprivation therapy between May 2009 and January 2017. Their median age, PSA level and PSA doubling time (PSA-DT) at the start of HS-RT\nwere 68 (53–74) years, 0.28 (0.20–0.79) ng/ml and 7.7 (2.3–38.5) months, respectively. A total dose of 60 Gy in 20 fractions (three times a week) was three-dimensionally delivered to the prostate bed. After a median follow-up\nof 62 (30–100) months, 19 (50%) patients developed a second BR after HS-RT, but only 1 patient died before the last follow-up. The 5-year overall survival and BR-free survival rates were 97.1 and 47.4%, respectively. Late grade 2\ngastrointestinal and genitourinary morbidities were observed in 0 and 5 (13%) patients, respectively. The PSA level as well as pathological T-stage and surgical margin status were regarded as significant predictive factors for a second\nBR by multivariate analysis. BR developed within 6 months after HS-RT in 11 (85%) of 13 patients with a PSADT < 10 months compared with 1 (17%) of 6 with a PSA-DT ≥ 10 months (median time to BR: 3 vs 14 months,\nP < 0.05). Despite the small number of patients, our HS-RT protocol seems feasible, and PSA kinetics may be useful for predicting the risk of BR and determining the appropriate follow-up schedule.\n","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Oxford University Press"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"32888035","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1093/jrr/rraa074","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://academic.oup.com/jrr/article/61/6/908/5901560","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1349-9157","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Ishikawa, Hitoshi"}],"nameIdentifiers":[{"nameIdentifier":"1011730","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Keiko Higuchi"}],"nameIdentifiers":[{"nameIdentifier":"1011731","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaminuma, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"1011732","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takezawa, Yutaka"}],"nameIdentifiers":[{"nameIdentifier":"1011733","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Yoshitaka"}],"nameIdentifiers":[{"nameIdentifier":"1011734","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Toru Etsunaga"}],"nameIdentifiers":[{"nameIdentifier":"1011735","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kazushi Maruo"}],"nameIdentifiers":[{"nameIdentifier":"1011736","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Hidemasa"}],"nameIdentifiers":[{"nameIdentifier":"1011737","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kubo, Nobuteru"}],"nameIdentifiers":[{"nameIdentifier":"1011738","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakano, Takashi"}],"nameIdentifiers":[{"nameIdentifier":"1011739","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mikio Kobayashi"}],"nameIdentifiers":[{"nameIdentifier":"1011740","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hitoshi, Ishikawa","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011741","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kaminuma, Takuya","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011742","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hidemasa, Kawamura","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011743","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nobuteru, Kubo","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011744","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takashi, Nakano","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1011745","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-12-03"},"publish_date":"2020-12-03","publish_status":"0","recid":"81181","relation_version_is_last":true,"title":["The effects of PSA kinetics on the outcome of hypofractionated salvage radiotherapy for biochemical recurrence of prostate cancer after prostatectomy "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:58:39.748326+00:00"}