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Harnessing PD-L1 interface peptide for PET imaging of PD-1 immune checkpoint
https://repo.qst.go.jp/records/81037
https://repo.qst.go.jp/records/81037fad91387-093b-411d-95a7-fafe80c3a075
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-23 | |||||
| タイトル | ||||||
| タイトル | Harnessing PD-L1 interface peptide for PET imaging of PD-1 immune checkpoint | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Xie, Lin× Zhang, Yiding× Hanyu, Masayuki× Ming-Rong, Zhang× Kuan, Hu× Xie, Lin× Zhang, Yiding× Hanyu, Masayuki× Ming-Rong, Zhang |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Interface peptides that mediate protein-protein interactions (PPI) are a class of important lead compounds for designing PPI inhibitors. However, their potential as precursors for radiotracers has never been exploited. Here we reported that the interface peptides from PD-L1 can be used in PET imaging of the PD-1 with high accuracy and sensitivity. Moreover, the performance differentiation between murine PD-L1 derived interface peptide (mPep-1) and human PD-L1 derived interface peptide (hPep-1) as PET tracers for PD-1 unveiled an unprecedented role of a non-critical residue in target binding, highlighting the significance of PET imaging as a companion diagnostics in drug development. Collectively, this study not only provided a first-of-its-kind peptide-based PET tracer for PD-1 but also conveyed a unique paradigm for develop ing imaging agents for highly challenging protein targets. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第60回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-11-13 | |||||
| 日付タイプ | Issued | |||||
