@misc{oai:repo.qst.go.jp:00081037,
 author = {Kuan, Hu and Xie, Lin and Zhang, Yiding and Hanyu, Masayuki and Ming-Rong, Zhang and Kuan, Hu and Xie, Lin and Zhang, Yiding and Hanyu, Masayuki and Ming-Rong, Zhang},
 month = {Nov},
 note = {Interface peptides that mediate protein-protein interactions (PPI) are a class of important lead compounds for designing PPI inhibitors. However, their potential as precursors for radiotracers has never been exploited. Here we reported that the interface peptides from PD-L1 can be used in PET imaging of the PD-1 with high accuracy and sensitivity. Moreover, the performance differentiation between murine PD-L1 derived interface peptide (mPep-1) and human PD-L1 derived interface peptide (hPep-1) as PET tracers for PD-1 unveiled an unprecedented role of a non-critical residue in target binding, highlighting the significance of PET imaging as a companion diagnostics in drug development. Collectively, this study not only provided a first-of-its-kind peptide-based PET tracer for PD-1 but also conveyed a unique paradigm for develop ing imaging agents for highly challenging protein targets., 第60回日本核医学会学術総会},
 title = {Harnessing PD-L1 interface peptide for PET imaging of PD-1 immune checkpoint},
 year = {2020}
}