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THE ANTIMALARIA DRUG ARTEMISININ DISPLAYS STRONG CYTOTOXIC EFFECT ON LEUKAEMIA LYMPHOCYTES IN COMBINATION WITH VITAMIN C AND PRO-VITAMIN K3
https://repo.qst.go.jp/records/81025
https://repo.qst.go.jp/records/81025e298ef37-2872-46f8-8838-4aab7f4aff0d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-17 | |||||
| タイトル | ||||||
| タイトル | THE ANTIMALARIA DRUG ARTEMISININ DISPLAYS STRONG CYTOTOXIC EFFECT ON LEUKAEMIA LYMPHOCYTES IN COMBINATION WITH VITAMIN C AND PRO-VITAMIN K3 | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
IVANOVA, D.
× IVANOVA, D.× YANEVA, Z.× BAKALOVA, R.× S. SEMKOVA× ZHELEV, ZH.× Bakalova, Rumiana |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This study investigated the anticancer effect of the anti-parasitic drug artemisinin in combination with two redox modulators: vitamin C and pro-vitamin K3 (C/K3) The experiments were conducted on leukaemia cells Jurkat. Cells were treated with either artemisinin or C/K3 alone and with all three compounds. Cell proliferation and viability were analysed using trypan blue stating and automated cell counting. The results showed that artemisinin (>10 M) suppressed cell proliferation activity, but did not induce cell death up to 500 M. The drug demonstrated a clear cytostatic effect at concentrations 250 500 M – Jurkat cells did not proliferate, but were alive. The combination C/K3 (200:2, 300:3 M/M) applied alone did not affect cell proliferation and viability. Vitamins C/K3 in concentration ratio 500:5 (μM/M) decreased cell proliferation activity by ~10%. The triple combination artemisinin/C/K3 manifested synergistic anti-proliferative effects at all concentration ratios analysed. This synergistic effect increased with increasing C/K3 concentration. Based on literature data, it was assumed that the anti-proliferative effect of the triple combination was mediated by changes in the redox-homeostasis of cancer cells. The C/K3 redox system likely acted on cancer mitochondria and increased superoxide production and activation of pro-apoptotic signals, specific for cancer cells. On the other hand, artemisinin could generate hydroxyl radicals as a result of activation of Fenton reactions, depleting intracellular reducing equivalents. Both redox mechanisms lead to activation of signal pathways for induction of cancer cell death. | |||||
| 書誌情報 |
Bulgarian Journal of Veterinary Medicine 巻 24, 号 4, p. 533-543, 発行日 2021-12 |
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| 出版者 | ||||||
| 出版者 | Thracian University, Faculty of Veterinary Medicine | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1311-1477 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.15547/bjvm.2019-0134 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | http://tru.uni-sz.bg/bjvm/BJVM%20December%202021%20p.533-543.pdf | |||||
