{"created":"2023-05-15T14:59:42.860363+00:00","id":81025,"links":{},"metadata":{"_buckets":{"deposit":"f3a804d7-67c2-43f5-a88a-49a1e6eaeeb2"},"_deposit":{"created_by":1,"id":"81025","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"81025"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00081025","sets":["1"]},"author_link":["1021794","1021797","1021795","1021798","1021796","1021793"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2021-12","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"4","bibliographicPageEnd":"543","bibliographicPageStart":"533","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"Bulgarian Journal of Veterinary Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"This study investigated the anticancer effect of the anti-parasitic drug artemisinin in combination with two redox modulators: vitamin C and pro-vitamin K3 (C/K3) The experiments were conducted on leukaemia cells Jurkat. Cells were treated with either artemisinin or C/K3 alone and with all three compounds. Cell proliferation and viability were analysed using trypan blue stating and automated cell counting. The results showed that artemisinin (>10 M) suppressed cell proliferation activity, but did not induce cell death up to 500 M. The drug demonstrated a clear cytostatic effect at concentrations 250 500 M – Jurkat cells did not proliferate, but were alive. The combination C/K3 (200:2, 300:3 M/M) applied alone did not affect cell proliferation and viability. Vitamins C/K3 in concentration ratio 500:5 (μM/M) decreased cell proliferation activity by ~10%. The triple combination artemisinin/C/K3 manifested synergistic anti-proliferative effects at all concentration ratios analysed. This synergistic effect increased with increasing C/K3 concentration. Based on literature data, it was assumed that the anti-proliferative effect of the triple combination was mediated by changes in the redox-homeostasis of cancer cells. The C/K3 redox system likely acted on cancer mitochondria and increased superoxide production and activation of pro-apoptotic signals, specific for cancer cells. On the other hand, artemisinin could generate hydroxyl radicals as a result of activation of Fenton reactions, depleting intracellular reducing equivalents. Both redox mechanisms lead to activation of signal pathways for induction of cancer cell death. ","subitem_description_type":"Abstract"}]},"item_8_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"Thracian University, Faculty of Veterinary Medicine"}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.15547/bjvm.2019-0134","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"http://tru.uni-sz.bg/bjvm/BJVM%20December%202021%20p.533-543.pdf","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1311-1477","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"IVANOVA, D."}],"nameIdentifiers":[{"nameIdentifier":"1021793","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YANEVA, Z."}],"nameIdentifiers":[{"nameIdentifier":"1021794","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"BAKALOVA, R."}],"nameIdentifiers":[{"nameIdentifier":"1021795","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"S. SEMKOVA"}],"nameIdentifiers":[{"nameIdentifier":"1021796","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"ZHELEV, ZH."}],"nameIdentifiers":[{"nameIdentifier":"1021797","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Bakalova, Rumiana","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"1021798","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"THE ANTIMALARIA DRUG ARTEMISININ DISPLAYS STRONG CYTOTOXIC EFFECT ON LEUKAEMIA LYMPHOCYTES IN COMBINATION WITH VITAMIN C AND PRO-VITAMIN K3 ","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"THE ANTIMALARIA DRUG ARTEMISININ DISPLAYS STRONG CYTOTOXIC EFFECT ON LEUKAEMIA LYMPHOCYTES IN COMBINATION WITH VITAMIN C AND PRO-VITAMIN K3 "}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-17"},"publish_date":"2020-11-17","publish_status":"0","recid":"81025","relation_version_is_last":true,"title":["THE ANTIMALARIA DRUG ARTEMISININ DISPLAYS STRONG CYTOTOXIC EFFECT ON LEUKAEMIA LYMPHOCYTES IN COMBINATION WITH VITAMIN C AND PRO-VITAMIN K3 "],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T18:16:54.370979+00:00"}