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胃がん肝転移に対するα線放射免疫療法の⾮臨床研究
https://repo.qst.go.jp/records/80951
https://repo.qst.go.jp/records/8095125a763c8-6a71-47ec-98c8-a4a0bff0f08e
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-13 | |||||
| タイトル | ||||||
| タイトル | 胃がん肝転移に対するα線放射免疫療法の⾮臨床研究 | |||||
| 言語 | ||||||
| 言語 | jpn | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
李, 惠子
× 李, 惠子× 長谷川, 純崇× Li, Huizi× Hasegawa, Sumitaka |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Liver metastasis (LM) is often found in patients with gastric cancer (GC) and the prognosis is miserable. HER2 is overexpressed in 7-34% of LMGC. Alpha-radioimmunotherapy (α-RIT) is expected to be a promising therapeutic option for metastasis with the combination of cancer specific drug delivery of antibody and high cell cytotoxicity of α-particle. Astatine 211 (At-211) is an attractive α-particle emitter with appropriate half-life and producible with cyclotron. We have investigated the therapeutic efficacy and toxicity of α-RIT with [At-211]-trastuzumab against LMGC using preclinical mice model. A single injection of [At-211]-trastuzumab effectively eradicated LMGC without recurrence in 6/8 mice and significantly prolonged the survival compared to control. There was no severe toxicity observed as long as we monitored. |
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| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第60回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-11-12 | |||||
| 日付タイプ | Issued | |||||
