@misc{oai:repo.qst.go.jp:00080951,
 author = {李, 惠子 and 長谷川, 純崇 and Li, Huizi and Hasegawa, Sumitaka},
 month = {Nov},
 note = {Liver metastasis (LM) is often found in patients with gastric cancer (GC) and the prognosis is miserable. HER2 is overexpressed in 7-34% of LMGC. Alpha-radioimmunotherapy (α-RIT) is expected to be a promising therapeutic option for metastasis with the combination of cancer specific drug delivery of antibody and high cell cytotoxicity of α-particle. Astatine 211 (At-211) is an attractive α-particle emitter with appropriate half-life and producible with cyclotron.
We have investigated the therapeutic efficacy and toxicity of α-RIT with [At-211]-trastuzumab against LMGC using preclinical mice model. A single injection of [At-211]-trastuzumab effectively eradicated LMGC without recurrence in 6/8 mice and significantly prolonged the survival compared to control. There was no severe toxicity observed as long as we monitored., 第60回日本核医学会学術総会},
 title = {胃がん肝転移に対するα線放射免疫療法の⾮臨床研究},
 year = {2020}
}