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Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts
https://repo.qst.go.jp/records/80905
https://repo.qst.go.jp/records/8090577219e6c-e865-4bf3-aaf7-5742bfbb5bde
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-06 | |||||
| タイトル | ||||||
| タイトル | Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes γ-Glutamyl Transferase Activities in vivo Tumor Xenografts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Seki, Tomohiro
× Seki, Tomohiro× Yamamoto, Kazutoshi× Oshima, Nobu× Itoda, Marino× Kondo, Yohei× Saito, Yutaro× Takakusagi, Yoichi× Kishimoto, Shun× Brender, Jeffery× Malinowski, Ronja× Jan, Henrik Ardenkjær-Larsen× Nonaka, Hiroshi× C Krishna, Murali× Sando, Shinsuke× Yoichi, Takakusagi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is well known that dysregulation of γ-glutamyl transferase (GGT) activities in malignant cells lead to more aggressive phenotypes by producing reactive oxygen species. GGT is important for glutathione homeostasis, and has also been used as a diagnostic marker for various pathologies in the liver, biliary system, and pancreas. Here, for the first time, a novel hyperpolarized 13C probe, γ-Glu-[1-13C]Gly, was demonstrated in vivo tumor xenografts, including human pancreatic ductal adenocarcinoma and ovarian adenocarcinoma, to detect real-time γ-glutamyl transferase activities as a prospective biomarker for monitoring the tumor progression and prognosis with/without various cancer therapeutic approaches. |
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| 書誌情報 |
Proceedings of ISMRM 2020 p. 3032, 発行日 2020-11 |
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| 出版者 | ||||||
| 出版者 | ISMRM | |||||
