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アイテム
Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts
https://repo.qst.go.jp/records/80904
https://repo.qst.go.jp/records/80904071f9196-47c5-4316-a034-53f1d62b137d
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-11-06 | |||||
| タイトル | ||||||
| タイトル | Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yamamoto, Kazutoshi
× Yamamoto, Kazutoshi× Seki, Tomohiro× Oshima, Nobu× Itoda, Marino× Kondo, Yohei× Saito, Yutaro× Takakusagi, Yoichi× Kishimoto, Shun× Brender, Jeffery× Malinowski, Ronja× Jan, Henrik Ardenkjær-Larsen× Nonaka, Hiroshi× Krishna, Murali× Sando, Shinsuke× Takakusagi, Yoichi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although the dissolution dynamic nuclear polarization approach overcomes the relatively poor MR sensitivity of in vivo metabolites, the limited number of available hyperpolarized 13C probes reminds a drawback. Here, we synthesized a novel gamma-glutamyl transferase (GGT) probe as a promising hyperpolarizing probe. It is well known that dysregulation of GGT activities in malignant cells leads to more aggressive phenotypes by producing reactive oxygen species. GGT is important for glutathione homeostasis and has been used as a diagnostic marker for various pathologies. In this presentation, for the first time, a novel hyperpolarized GGT probe was demonstrated in vivo human tumor xenografts to detect real-time GGT as a prospective biomarker for monitoring the tumor progression and prognosis with/without cancer therapeutic approaches. | |||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 61st ENC | |||||
| 発表年月日 | ||||||
| 日付 | 2020-03-09 | |||||
| 日付タイプ | Issued | |||||
