{"created":"2023-05-15T14:59:37.607890+00:00","id":80904,"links":{},"metadata":{"_buckets":{"deposit":"88a6f10c-b5a7-4d2c-a78f-10ee296d3489"},"_deposit":{"created_by":1,"id":"80904","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"80904"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00080904","sets":["10:29"]},"author_link":["899259","899253","899258","899261","899249","899257","899260","899252","899255","899263","899256","899250","899251","899262","899254"],"item_10005_date_7":{"attribute_name":"発表年月日","attribute_value_mlt":[{"subitem_date_issued_datetime":"2020-03-09","subitem_date_issued_type":"Issued"}]},"item_10005_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although the dissolution dynamic nuclear polarization approach overcomes the relatively poor MR sensitivity of in vivo metabolites, the limited number of available hyperpolarized 13C probes reminds a drawback. Here, we synthesized a novel gamma-glutamyl transferase (GGT) probe as a promising hyperpolarizing probe. It is well known that dysregulation of GGT activities in malignant cells leads to more aggressive phenotypes by producing reactive oxygen species. GGT is important for glutathione homeostasis and has been used as a diagnostic marker for various pathologies. In this presentation, for the first time, a novel hyperpolarized GGT probe was demonstrated in vivo human tumor xenografts to detect real-time GGT as a prospective biomarker for monitoring the tumor progression and prognosis with/without cancer therapeutic approaches. ","subitem_description_type":"Abstract"}]},"item_10005_description_6":{"attribute_name":"会議概要（会議名, 開催地, 会期, 主催者等）","attribute_value_mlt":[{"subitem_description":"61st ENC","subitem_description_type":"Other"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Yamamoto, Kazutoshi"}],"nameIdentifiers":[{"nameIdentifier":"899249","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Tomohiro"}],"nameIdentifiers":[{"nameIdentifier":"899250","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Oshima, Nobu"}],"nameIdentifiers":[{"nameIdentifier":"899251","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Itoda, Marino"}],"nameIdentifiers":[{"nameIdentifier":"899252","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kondo, Yohei"}],"nameIdentifiers":[{"nameIdentifier":"899253","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Saito, Yutaro"}],"nameIdentifiers":[{"nameIdentifier":"899254","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Yoichi"}],"nameIdentifiers":[{"nameIdentifier":"899255","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kishimoto, Shun"}],"nameIdentifiers":[{"nameIdentifier":"899256","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Brender, Jeffery"}],"nameIdentifiers":[{"nameIdentifier":"899257","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Malinowski, Ronja"}],"nameIdentifiers":[{"nameIdentifier":"899258","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Jan, Henrik Ardenkjær-Larsen"}],"nameIdentifiers":[{"nameIdentifier":"899259","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nonaka, Hiroshi"}],"nameIdentifiers":[{"nameIdentifier":"899260","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Krishna, Murali"}],"nameIdentifiers":[{"nameIdentifier":"899261","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sando, Shinsuke"}],"nameIdentifiers":[{"nameIdentifier":"899262","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takakusagi, Yoichi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"899263","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"conference object","resourceuri":"http://purl.org/coar/resource_type/c_c94f"}]},"item_title":"Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts"}]},"item_type_id":"10005","owner":"1","path":["29"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-11-06"},"publish_date":"2020-11-06","publish_status":"0","recid":"80904","relation_version_is_last":true,"title":["Novel Real-time Hyperpolarized 13C Metabolic Tracer Probes gamma-Glutamyl Transferase Activities in vivo Human Tumor Xenografts"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:20:04.424200+00:00"}