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Binding of dopamine D1 receptor and noradrenaline transporter in individuals with autism spectrum disorder: A PET study
https://repo.qst.go.jp/records/80853
https://repo.qst.go.jp/records/808533c41c593-991e-4151-bad4-12470e25e03d
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-07-16 | |||||
| タイトル | ||||||
| タイトル | Binding of dopamine D1 receptor and noradrenaline transporter in individuals with autism spectrum disorder: A PET study | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kubota, Manabu
× Kubota, Manabu× Fujino, Junya× Tei, Shisei× Takahata, Keisuke× Matsuoka, Kiwamu× Tagai, Kenji× Sano, Yasunori× Yamamoto, Yasuharu× Shimada, Hitoshi× Takado, Yuhei× Seki, Chie× Itahashi, Takashi× Y. Aoki, Yuta× Ohta, Haruhisa× Ryu-ichiro, Hashimoto× Ming-Rong, Zhang× Suhara, Tetsuya× Nakamura, Motoaki× Takahashi, Hidehiko× Kato, Nobumasa× Higuchi, Makoto× Manabu, Kubota× Keisuke, Takahata× Kiwamu, Matsuoka× Kenji, Tagai× Yasunori, Sano× Yamamoto, Yasuharu× Hitoshi, Shimada× Yuhei, Takado× Chie, Seki× Zhang, Ming-Rong× Tetsuya, Suhara× Hidehiko, Takahashi× Makoto, Higuchi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few studies have examined these neurotransmissions in individuals with ASD in vivo. Here, we investigated DA D1 receptor (D1R) and noradrenaline transporter (NAT) binding in adults with ASD (n = 18) and neurotypical controls (n = 20) by utilizing two different PET radioligands, [11C]SCH23390 and (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences in DA D1R (striatum, anterior cingulate cortex, temporal cortex) or NAT (thalamus, pons) binding. However, in the ASD group, there were significant negative correlations between DA D1R binding (striatum, anterior cingulate cortex, temporal cortex) and the “attention to detail” subscale score of the Autism Spectrum Quotient. Further, there was a significant positive correlation between DA D1R binding (temporal cortex) and emotion perception ability assessed by the neurocognitive battery. Associations of NAT binding with empathic abilities and executive function were found in controls, but were absent in the ASD group. While a lack of significant group differences in binding might be partly due to the heterogeneity of ASD, our results indicate that central DA and NA function might play certain roles in the clinical characteristics of ASD. | |||||
| 書誌情報 |
Cerebral Cortex 巻 30, 号 12, p. 6458-6468, 発行日 2020-08 |
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| 出版者 | ||||||
| 出版者 | Oxford University Press | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1047-3211 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32770189 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1093/cercor/bhaa211 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://academic.oup.com/cercor/article/30/12/6458/5882176 | |||||
