@article{oai:repo.qst.go.jp:00080853,
 author = {Kubota, Manabu and Fujino, Junya and Tei, Shisei and Takahata, Keisuke and Matsuoka, Kiwamu and Tagai, Kenji and Sano, Yasunori and Yamamoto, Yasuharu and Shimada, Hitoshi and Takado, Yuhei and Seki, Chie and Itahashi, Takashi and Y. Aoki, Yuta and Ohta, Haruhisa and Ryu-ichiro, Hashimoto and Ming-Rong, Zhang and Suhara, Tetsuya and Nakamura, Motoaki and Takahashi, Hidehiko and Kato, Nobumasa and Higuchi, Makoto and Manabu, Kubota and Keisuke, Takahata and Kiwamu, Matsuoka and Kenji, Tagai and Yasunori, Sano and Yamamoto, Yasuharu and Hitoshi, Shimada and Yuhei, Takado and Chie, Seki and Zhang, Ming-Rong and Tetsuya, Suhara and Hidehiko, Takahashi and Makoto, Higuchi},
 issue = {12},
 journal = {Cerebral Cortex},
 month = {Aug},
 note = {Although previous studies have suggested the involvement of dopamine (DA) and noradrenaline (NA) neurotransmissions in the autism spectrum disorder (ASD) pathophysiology, few studies have examined these neurotransmissions in individuals with ASD in vivo. Here, we investigated DA D1 receptor (D1R) and noradrenaline transporter (NAT) binding in adults with ASD (n = 18) and neurotypical controls (n = 20) by utilizing two different PET radioligands, [11C]SCH23390 and (S,S)-[18F]FMeNER-D2, respectively. We found no significant group differences in DA D1R (striatum, anterior cingulate cortex, temporal cortex) or NAT (thalamus, pons) binding. However, in the ASD group, there were significant negative correlations between DA D1R binding (striatum, anterior cingulate cortex, temporal cortex) and the “attention to detail” subscale score of the Autism Spectrum Quotient. Further, there was a significant positive correlation between DA D1R binding (temporal cortex) and emotion perception ability assessed by the neurocognitive battery. Associations of NAT binding with empathic abilities and executive function were found in controls, but were absent in the ASD group. While a lack of significant group differences in binding might be partly due to the heterogeneity of ASD, our results indicate that central DA and NA function might play certain roles in the clinical characteristics of ASD.},
 pages = {6458--6468},
 title = {Binding of dopamine D1 receptor and noradrenaline transporter in individuals with autism spectrum disorder: A PET study},
 volume = {30},
 year = {2020}
}