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Radiation engenders conversed migration and invasion in colorectal cancer cells through opposite modulation of ANXA2/ AKT /GSK3β pathway
https://repo.qst.go.jp/records/80797
https://repo.qst.go.jp/records/807977bdde3a9-912d-4f79-9e7c-09c422a40fed
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-05-20 | |||||
| タイトル | ||||||
| タイトル | Radiation engenders conversed migration and invasion in colorectal cancer cells through opposite modulation of ANXA2/ AKT /GSK3β pathway | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Pan, Han
× Pan, Han× Song, Yimeng× Zhang, Hang× Bai, Yang× Konishi, Teruaki× Kobayashi, Alisa× Shao, Chunlin× Pan, Yan× Teruaki, Konishi× Alisa, Kobayashi |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | BACKGROUND: Conventional radiation may either promote or inhibit tumor metastatic potential paradoxically, but the underlying mechanism remains vague, and the knowledge concerning the changes of metastatic potential after heavy ion radiation is still limited. METHODSs: we detected the changes of the metastasis capacities of two colorectal cancer (CRC) cell lines after γ- or c-ion radiation, and investigated the underlying molecular mechanisms using western blot, immunoprecipitation, LC-MS/MS and siRNA transfection. RESULTS: The change of the migration and invasion potential showed a completely reversed pattern in these two cell lines after γ-or carbon ion radiation both in vivo and vitro. Radiation induced EMT in DLD-1 cells, but MET in HCT116 cells, which was due to the opposite modulation of ANXA2/AKT/GSK3β signaling pathway in CRC cells. ANAX2 could bind directly with GSK3β and act as a negative regulator of its activation. Knocking-down ANXA2 gene not only decreased the migration in nonirradiated CRC cells, but also reversed the enhanced migration in irradiated DLD-1 cells and strengthened radiation-impaired migration in HCT116 cells. CONCLUSION: The change of cellular motility after radiation is independent of radiation type, but is correlated with the inherent of cells, and ANXA2 is applicable to be a potential target for radiotherapy. |
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| 書誌情報 |
American Journal of Cancer Research 巻 11, 号 1, p. 61-78, 発行日 2020-10 |
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| 出版者 | ||||||
| 出版者 | e-Century Publishing Corporation | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2156-6976 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://e-century.us/files/ajcr/11/1/ajcr0121599.pdf | |||||
