@article{oai:repo.qst.go.jp:00080797,
 author = {Pan, Han and Song, Yimeng and Zhang, Hang and Bai, Yang and Konishi, Teruaki and Kobayashi, Alisa and Shao, Chunlin and Pan, Yan and Teruaki, Konishi and Alisa, Kobayashi},
 issue = {1},
 journal = {American Journal of Cancer Research},
 month = {Oct},
 note = {BACKGROUND: Conventional radiation may either promote or inhibit tumor metastatic potential paradoxically, but the underlying mechanism remains vague, and the knowledge concerning the changes of metastatic potential after heavy ion radiation is still limited. 
METHODSs: we detected the changes of the metastasis capacities of two colorectal cancer (CRC) cell lines after γ- or c-ion radiation, and investigated the underlying molecular mechanisms using western blot, immunoprecipitation, LC-MS/MS and siRNA transfection. 
RESULTS: The change of the migration and invasion potential showed a completely reversed pattern in these two cell lines after γ-or carbon ion radiation both in vivo and vitro. Radiation induced EMT in DLD-1 cells, but MET in HCT116 cells, which was due to the opposite modulation of ANXA2/AKT/GSK3β signaling pathway in CRC cells. ANAX2 could bind directly with GSK3β and act as a negative regulator of its activation. Knocking-down ANXA2 gene not only decreased the migration in nonirradiated CRC cells, but also reversed the enhanced migration in irradiated DLD-1 cells and strengthened radiation-impaired migration in HCT116 cells. 
CONCLUSION: The change of cellular motility after radiation is independent of radiation type, but is correlated with the inherent of cells, and ANXA2 is applicable to be a potential target for radiotherapy.},
 pages = {61--78},
 title = {Radiation engenders conversed migration and invasion in colorectal cancer cells through opposite modulation of ANXA2/ AKT /GSK3β pathway},
 volume = {11},
 year = {2020}
}