WEKO3
アイテム
PET Imaging of VEGFR with a Novel <SUP>64</SUP>Cu Labeled Peptide
https://repo.qst.go.jp/records/80788
https://repo.qst.go.jp/records/807886554fcf7-4412-4b34-a7e0-9ce2aae5b925
| Item type | 会議発表用資料 / Presentation(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-23 | |||||
| タイトル | ||||||
| タイトル | PET Imaging of VEGFR with a Novel <SUP>64</SUP>Cu Labeled Peptide | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_c94f | |||||
| 資源タイプ | conference object | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Xie, Lin× Zhang, Yiding× Hanyu, Masayuki× Ming-Rong, Zhang× Kuan, Hu× Xie, Lin× Zhang, Yiding× Hanyu, Masayuki× Ming-Rong, Zhang |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Vascular endothelial growth factor receptors (VEGFRs) are well recognized as significant biomarkers of tumor angiogenesis. Herein, we have developed a f irst－of－its-kind peptide－based VEGFR positron emission tomography (PET) t racer. The novel [64Cu]VEGF125－136 peptide possessed satisfactory radio－ch aracteristics and showed good specificity for the visualization of VEGFR in various mouse models, in which the tumorspecific radioactivity uptake was hi ghly correlated to the VEGFR expression level. Moreover, the tracer showed h igh tumor uptake (ca. 5.89 %ID/g at 20 min postinjection in B16F10 mice) and excellent pharmacokinetics, achieving the maximum imaging quality within 1 h after injection. These features convey [64Cu]VEGF125－136 as a promising, clinically translatable PET tracer for the imaging of tumor angiogenesis. |
|||||
| 会議概要（会議名, 開催地, 会期, 主催者等） | ||||||
| 内容記述タイプ | Other | |||||
| 内容記述 | 第60回日本核医学会学術総会 | |||||
| 発表年月日 | ||||||
| 日付 | 2020-11-13 | |||||
| 日付タイプ | Issued | |||||
