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Systemic Synuclein Sampling Study toward a Parkinson disease biomarker
https://repo.qst.go.jp/records/80771
https://repo.qst.go.jp/records/80771a7324c9b-2b8b-4b83-96ba-e0ed40d83441
| Item type | 会議発表論文 / Conference Paper(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-10-21 | |||||
| タイトル | ||||||
| タイトル | Systemic Synuclein Sampling Study toward a Parkinson disease biomarker | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_5794 | |||||
| 資源タイプ | conference paper | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Shinoto, Hitoshi
× Shinoto, Hitoshi× Tokuda, Takahiko× Shinoto, Hitoshi× Tokuda, Takahiko |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | This article requires a subscription to view the full text. If you have a subscription you may use the login form below to view the article. Access to this article can also be purchased. The search for an accurate, reliable, early disease biomarker for Parkinson disease (PD) from an easily accessible source is a high priority.1 α-Synuclein (α-Syn) is a small protein largely present in the CNS at the presynaptic neuronal terminals. The cause of PD is not clear, but aggregation or posttranslational modifications of α-Syn are currently thought to be an essential link in the chain of events leading to PD.1,2 Lewy type α-Syn deposition is found not only in the CNS but also in the peripheral nervous system of multiple organs including the endocrine glands, skin, stomach, and colon in PD with rostral-caudal gradient within the gastrointestinal gract.1,3 α-Syn is normally released by neuronal cells and is present in CSF and plasma. |
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| 書誌情報 |
Neurology 巻 95, 号 9, p. 373-374, 発行日 2020-09 |
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| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1212/WNL.0000000000010428 | |||||
