WEKO3
アイテム
Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer
https://repo.qst.go.jp/records/80304
https://repo.qst.go.jp/records/803044f5947b3-b513-4c6f-8fdd-727cefca5df4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-30 | |||||
| タイトル | ||||||
| タイトル | Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kato, Kazuhiro
× Kato, Kazuhiro× Nagane, Masaki× Aihara, Naoyuki× Kamiie, Junichi× Miyanabe, Masakatsu× Hiraki, Shinobu× Nakanishi, Ikuo× Shoji, Yoshimi× Ken-ichiro, Matsumoto× Yamashita, Tadashi× Kazuhiro, Kato× Ikuo, Nakanishi× Yoshimi, Shoji× Kenichiro, Matsumoto |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Polyphenols are abundant in vegetables and fruit. They have been shown to have various antitumor, antioxidant, and anti-inflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato ( Ipomoea batatas) . These lipid-soluble polyphenols (PPL) mainly contained caffeic acid derivatives with strong antioxidant ability, which we hypothesized to affect diseases for which oxidative stress is a factor, such as cancer. We therefore investigated the antitumor and chemosensitizing effects of PPL on E0771 murine breast cancer cells. The PPL accumulated in the cells’ cytoplasm due to its high lipophilicity, and reduced reactive oxygen species through its strong antioxidant activity. The PPL also arrested the cell cycle at G 0 /G 1 by suppressing Akt activity, and enhanced the cytotoxicity of anticancer agents. In this model, PPL inhibited tumor growth and enhanced the efficacy of chemotherapy drugs. These results suggest the potential of PPL as a functional food to support cancer therapy. | |||||
| 書誌情報 |
Journal of Clinical Biochemistry and Nutrition 巻 68, 号 3, p. 193-200, 発行日 2020-08 |
|||||
| 出版者 | ||||||
| 出版者 | 日本酸化ストレス学会 | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0912-0009 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.3164/jcbn.20-73 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/jcbn/advpub/0/advpub_20-73/_article/-char/ja/ | |||||
