@article{oai:repo.qst.go.jp:00080304,
 author = {Kato, Kazuhiro and Nagane, Masaki and Aihara, Naoyuki and Kamiie, Junichi and Miyanabe, Masakatsu and Hiraki, Shinobu and Nakanishi, Ikuo and Shoji, Yoshimi and Ken-ichiro, Matsumoto and Yamashita, Tadashi and Kazuhiro, Kato and Ikuo, Nakanishi and Yoshimi, Shoji and Kenichiro, Matsumoto},
 issue = {3},
 journal = {Journal of Clinical Biochemistry and Nutrition},
 month = {Aug},
 note = {Polyphenols are abundant in vegetables and fruit. They have been shown to have various antitumor, antioxidant, and anti-inflammatory effects. Here, we extracted the lipid-soluble fraction of polyphenols from fermented sweet potato ( Ipomoea batatas) . These lipid-soluble polyphenols (PPL) mainly contained caffeic acid derivatives with strong antioxidant ability, which we hypothesized to affect diseases for which oxidative stress is a factor, such as cancer. We therefore investigated the antitumor and chemosensitizing effects of PPL on E0771 murine breast cancer cells. The PPL accumulated in the cells’ cytoplasm due to its high lipophilicity, and reduced reactive oxygen species through its strong antioxidant activity. The PPL also arrested the cell cycle at G 0 /G 1 by suppressing Akt activity, and enhanced the cytotoxicity of anticancer agents. In this model, PPL inhibited tumor growth and enhanced the efficacy of chemotherapy drugs. These results suggest the potential of PPL as a functional food to support cancer therapy.},
 pages = {193--200},
 title = {Lipid-soluble polyphenols from sweet potato exert antitumor activity and enhance chemosensitivity in breast cancer},
 volume = {68},
 year = {2020}
}