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Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds.
https://repo.qst.go.jp/records/80209
https://repo.qst.go.jp/records/802098dce6836-f854-41f3-a18c-34fab2eff388
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-07-20 | |||||
| タイトル | ||||||
| タイトル | Folate-appended cyclodextrin improves the intratumoral accumulation of existing boron compounds. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Matsumoto, Yoshitaka
× Matsumoto, Yoshitaka× Hattori, Kenjiro× Arima, Hidetoshi× Motoyama, Keiichi× Higashi, Taishi× Ishikawa, Hitoshi× Fukumitsu, Nobuyoshi× Aihara, Teruhito× Nakai, Kei× Kumada, Hiroaki× Sakurai, Hideyuki× Matsumoto, Yoshitaka× Ishikawa, Hitoshi× Nakai, Kei× Sakurai, Hideyuki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | In this study, the tumor accumulation and antitumor effect of folate-modified cyclodextrin (ND201) purified with folate receptor (FR) connotated with BSH were examined. ND201 and BSH were stably bound in blood, and the mixing ratio 1:1 was most efficient. ND-BSH showed higher boron concentration (38.5 ppm) than BSH alone (11.25 ppm). The maximum ND-BSH tumor/blood ratio was also markedly higher (6.58) than that of BSH alone (1.04). ND-BSH showed a significant antitumor effect compared with BSH after neutron irradiation. | |||||
| 書誌情報 |
Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine 巻 163, p. 109201, 発行日 2020-09 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0969-8043 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32561042 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1016/j.apradiso.2020.109201 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.sciencedirect.com/science/article/pii/S0969804320303304 | |||||
