WEKO3
アイテム
Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy
https://repo.qst.go.jp/records/80108
https://repo.qst.go.jp/records/80108d7642436-a3b3-46ac-8978-9279e373d543
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-22 | |||||
| タイトル | ||||||
| タイトル | Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Kuan, Hu
× Kuan, Hu× Xie, Lin× Zhang, Yiding× Hanyu, Masayuki× Yang, Zhimin× Nagatsu, Kotaro× Suzuki, Hisashi× Ouyang, Jiang× Ji, Xiaoyuan× Wei, Junjie× Xu, Hao× C. Farokhzad, Omid× Liang, Huan× Lu, Wang× Tao, Wei× Ming-Rong, Zhang× Kuan, Hu× Lin, Xie× Zhang, Yiding× Masayuki, Hanyu× Yang, Zhimin× Kotaro, Nagatsu× Hisashi, Suzuki× Liang, Huan× Lu, Wang× Zhang, Ming-Rong |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | The use of photothermal agents (PTAs) in cancer photothermal therapy (PTT) has shown promising results in clinical studies. The rapid degradation of PTAs may address safety concerns but usually limits the photothermal stability required for efficacious treatment. Conversely, PTAs with high photothermal stability usually degrade slowly. The solutions that address the balance between the high photothermal stability and rapid degradation of PTAs are rare. Here, we report that the inherent Cu2+-capturing ability of black phosphorus (BP) can accelerate the degradation of BP, while also enhancing photothermal stability. The incorporation of Cu2+ into BP@Cu nanostructures further enables chemodynamic therapy (CDT)-enhanced PTT. Moreover, by employing 64Cu2+, positron emission tomography (PET) imaging can be achieved for in vivo real-time and quantitative tracking. Therefore, our study not only introduces an “ideal” PTA that bypasses the limitations of PTAs, but also provides the proof-of-concept application of BP-based materials in PET-guided, CDT-enhanced combination cancer therapy. | |||||
| 書誌情報 |
nature communications 巻 11, p. 2778-1-15, 発行日 2020-06 |
|||||
| 出版者 | ||||||
| 出版者 | nature research | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2041-1723 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41467-020-16513-0 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41467-020-16513-0 | |||||
