@article{oai:repo.qst.go.jp:00080108,
 author = {Kuan, Hu and Xie, Lin and Zhang, Yiding and Hanyu, Masayuki and Yang, Zhimin and Nagatsu, Kotaro and Suzuki, Hisashi and Ouyang, Jiang and Ji, Xiaoyuan and Wei, Junjie and Xu, Hao and C. Farokhzad, Omid and Liang, Huan and Lu, Wang and Tao, Wei and Ming-Rong, Zhang and Kuan, Hu and Lin, Xie and Zhang, Yiding and Masayuki, Hanyu and Yang, Zhimin and Kotaro, Nagatsu and Hisashi, Suzuki and Liang, Huan and Lu, Wang and Zhang, Ming-Rong},
 journal = {nature communications},
 month = {Jun},
 note = {The use of photothermal agents (PTAs) in cancer photothermal therapy (PTT) has shown promising results in clinical studies. The rapid degradation of PTAs may address safety concerns but usually limits the photothermal stability required for efficacious treatment. Conversely, PTAs with high photothermal stability usually degrade slowly. The solutions that address the balance between the high photothermal stability and rapid degradation of PTAs are rare. Here, we report that the inherent Cu2+-capturing ability of black phosphorus (BP) can accelerate the degradation of BP, while also enhancing photothermal stability. The incorporation of Cu2+ into BP@Cu nanostructures further enables chemodynamic therapy (CDT)-enhanced PTT. Moreover, by employing 64Cu2+, positron emission tomography (PET) imaging can be achieved for in vivo real-time and quantitative tracking. Therefore, our study not only introduces an “ideal” PTA that bypasses the limitations of PTAs, but also provides the proof-of-concept application of BP-based materials in PET-guided, CDT-enhanced combination cancer therapy.},
 pages = {2778-1--15},
 title = {Marriage of black phosphorus and Cu2+ as effective photothermal agents for PET-guided combination cancer therapy},
 volume = {11},
 year = {2020}
}