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Proton beam therapy is a safe and effective treatment in elderly patients with esophageal squamous cell carcinoma
https://repo.qst.go.jp/records/80055
https://repo.qst.go.jp/records/80055259e0500-2948-4a1f-838a-c38b15cd83e1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-10 | |||||
| タイトル | ||||||
| タイトル | Proton beam therapy is a safe and effective treatment in elderly patients with esophageal squamous cell carcinoma | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Ono, Takashi
× Ono, Takashi× Wada, Hitoshi× Ishikawa, Hitoshi× Tamamura, Hiroyasu× Tokumaru, Sunao× Ono, Takashi× Ishikawa, Hitoshi× Tokumaru, Sunao |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Background: There are many elderly patients with esophageal squamous cell carcinoma (ESCC). However, there are currently few articles regarding the clinical outcome following proton beam therapy in these patients. The purpose of this study was to evaluate the clinical results of proton beam therapy in elderly patients with ESCC. Methods: Between January 2009 and December 2013, patients aged ≥75 years who underwent proton beam therapy were examined using multi-institutional data from Japan. Results: There were 38 inoperable patients (70.4%) and 16 operable patients (29.6%). More than 40% of patients had stage III/IV ESCC. The five-year overall and cancer-specific survival rates were 56.2% and 71.7%, respectively. Performance status was the only factor that significantly influenced overall survival during the multivariate analysis. The five-year local control rate was 61.8%, and local recurrence occurred within 13 months in 82.4% of patients,. There was no grade 3 or higher toxicity, excluding three patients with grade 3 esophageal ulcers. Conclusions: In conclusion, proton beam therapy may become an alternative treatment with lower toxicity in elderly patients with ESCC, compared to surgery or conventional X-ray radiotherapy. This includes inoperable patients. |
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| 書誌情報 |
Thoracic Cancer 巻 11, 号 8, p. 2170-2177, 発行日 2020-05 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1759-7706 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32510875 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1111/1759-7714.13524 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1111/1759-7714.13524 | |||||
