@article{oai:repo.qst.go.jp:00080055,
 author = {Ono, Takashi and Wada, Hitoshi and Ishikawa, Hitoshi and Tamamura, Hiroyasu and Tokumaru, Sunao and Ono, Takashi and Ishikawa, Hitoshi and Tokumaru, Sunao},
 issue = {8},
 journal = {Thoracic Cancer},
 month = {May},
 note = {Background: There are many elderly patients with esophageal squamous cell
carcinoma (ESCC). However, there are currently few articles regarding the clinical outcome following proton beam therapy in these patients. The purpose of this study was to evaluate the clinical results of proton beam therapy in elderly
patients with ESCC.
Methods: Between January 2009 and December 2013, patients aged ≥75 years
who underwent proton beam therapy were examined using multi-institutional
data from Japan.
Results: There were 38 inoperable patients (70.4%) and 16 operable patients
(29.6%). More than 40% of patients had stage III/IV ESCC. The five-year overall
and cancer-specific survival rates were 56.2% and 71.7%, respectively. Performance status was the only factor that significantly influenced overall survival during the multivariate analysis. The five-year local control rate was 61.8%, and local recurrence occurred within 13 months in 82.4% of patients,. There was no grade 3 or higher toxicity, excluding three patients with grade 3 esophageal ulcers.
Conclusions: In conclusion, proton beam therapy may become an alternative
treatment with lower toxicity in elderly patients with ESCC, compared to surgery
or conventional X-ray radiotherapy. This includes inoperable patients.},
 pages = {2170--2177},
 title = {Proton beam therapy is a safe and effective treatment in elderly patients with esophageal squamous cell carcinoma},
 volume = {11},
 year = {2020}
}