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Enhanced MRI-Guided Gadolinium (III) Neutron Capture Therapyby Polymeric Nanocarriers Promoting Tumor Accumulation andIntracellular Delivery
https://repo.qst.go.jp/records/80043
https://repo.qst.go.jp/records/80043a3017159-3302-47f7-b067-773dad074aa1
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-06-09 | |||||
| タイトル | ||||||
| タイトル | Enhanced MRI-Guided Gadolinium (III) Neutron Capture Therapyby Polymeric Nanocarriers Promoting Tumor Accumulation andIntracellular Delivery | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Qin, Changyuan
× Qin, Changyuan× Hou, Xuan× Khan, Thahomina× Nitta, Nobuhiro× Yanagawa, Masashi× Sakurai , Yuriko× Suzuki, Minoru× Shin‐Ichiro, Masunaga× Tanaka, Hiroki× Sakurai, Yoshinori× Takahashi, Hiroyuki× Aoki, Ichio× Yanagie, Hironobu× Nobuhiro, Nitta× Ichio, Aoki |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Gadolinium(III) (Gd(III)) chelates are promising compounds for developing MRI‐guided neutron capture therapies (NCT). However, despite their success as MRI contrast agents (CAs), current Gd(III) chelates do not present appropriate accumulation in tumors for effective NCT. To overcome this limitation, we developed a series of biocompatible polymeric nanocarriers conjugating Gd(III)‐chelates, i. e. Gd‐DOTA, as NCT agents with high MRI sensitivity and tumor delivery. These polymers were based on poly(aspartic acid) (P(Asp)) and were modified with poly(ethylene glycol) (PEG) chains having different molecular weight (Mw) for controlling stability and pharmacokinetics. The T1 relaxivity of the Gd‐DOTA conjugated polymers increased 2‐fold compared to that of clinically used Gd(III) CAs. In vivo, the PEG‐modified polymers promoted the accumulation in tumor tissues, enhancing the MRI contrast of tumors. After neutron irradiation, the nanocarriers effectively suppressed the tumor growth, particularly the PEG‐P(Asp‐Gd‐DOTA) with shorter PEG chain, which promoted higher intracellular delivery, supporting their potential as NCT agents. | |||||
| 書誌情報 |
ChemNanoMat 巻 6, 号 3, p. 412-419, 発行日 2020-03 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2199-692X | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1002/cnma.201900730 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://onlinelibrary.wiley.com/doi/full/10.1002/cnma.201900730 | |||||
