@article{oai:repo.qst.go.jp:00080043,
 author = {Qin, Changyuan and Hou, Xuan and Khan, Thahomina and Nitta, Nobuhiro and Yanagawa, Masashi and Sakurai , Yuriko and Suzuki, Minoru and Shin‐Ichiro, Masunaga and Tanaka, Hiroki and Sakurai, Yoshinori and Takahashi, Hiroyuki and Aoki, Ichio and Yanagie, Hironobu and Nobuhiro, Nitta and Ichio, Aoki},
 issue = {3},
 journal = {ChemNanoMat},
 month = {Mar},
 note = {Gadolinium(III) (Gd(III)) chelates are promising compounds for developing MRI‐guided neutron capture therapies (NCT). However, despite their success as MRI contrast agents (CAs), current Gd(III) chelates do not present appropriate accumulation in tumors for effective NCT. To overcome this limitation, we developed a series of biocompatible polymeric nanocarriers conjugating Gd(III)‐chelates, i. e. Gd‐DOTA, as NCT agents with high MRI sensitivity and tumor delivery. These polymers were based on poly(aspartic acid) (P(Asp)) and were modified with poly(ethylene glycol) (PEG) chains having different molecular weight (Mw) for controlling stability and pharmacokinetics. The T1 relaxivity of the Gd‐DOTA conjugated polymers increased 2‐fold compared to that of clinically used Gd(III) CAs. In vivo, the PEG‐modified polymers promoted the accumulation in tumor tissues, enhancing the MRI contrast of tumors. After neutron irradiation, the nanocarriers effectively suppressed the tumor growth, particularly the PEG‐P(Asp‐Gd‐DOTA) with shorter PEG chain, which promoted higher intracellular delivery, supporting their potential as NCT agents.},
 pages = {412--419},
 title = {Enhanced MRI-Guided Gadolinium (III) Neutron Capture Therapyby Polymeric Nanocarriers Promoting Tumor Accumulation andIntracellular Delivery},
 volume = {6},
 year = {2020}
}