WEKO3
アイテム
Immuno-OpenPET: a novel approach for early diagnosis and image-guided surgery for small resectable pancreatic cancer.
https://repo.qst.go.jp/records/79896
https://repo.qst.go.jp/records/7989617bbf034-d6ff-49ea-a6f4-79e9050ce74b
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-16 | |||||
| タイトル | ||||||
| タイトル | Immuno-OpenPET: a novel approach for early diagnosis and image-guided surgery for small resectable pancreatic cancer. | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Yoshii, Yukie
× Yoshii, Yukie× Tashima, Hideaki× Iwao, Yuma× Yoshida, Eiji× Wakizaka, Hidekatsu× Akamatsu, Go× Yamaya, Taiga× Matsumoto, Hiroki× Yoshimoto, Mitsuyoshi× Igarashi, Chika× Hihara, Fukiko× Tachibana, Tomoko× Ming-Rong, Zhang× Nagatsu, Kotaro× Sugyo, Aya× B Tsuji, Atsushi× Higashi, Tatsuya× Yoshii, Yukie× Tashima, Hideaki× Iwao, Yuma× Yoshida, Eiji× Wakizaka, Hidekatsu× Akamatsu, Go× Yamaya, Taiga× Matsumoto, Hiroki× Yoshimoto, Mitsuyoshi× Igarashi, Chika× Hihara, Fukiko× Tachibana, Tomoko× Ming-Rong, Zhang× Nagatsu, Kotaro× Sugyo, Aya× Tsuji, Atsushi× Higashi, Tatsuya |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Pancreatic cancer (PC) has a poor prognosis owing to difficulties in the diagnosis of resectable PC at early stages. Several clinical studies have indicated that the detection and surgery of small resectable PC (<1 cm) can significantly improve survival; however, imaging diagnosis and accurate resection of small PC remain challenging. Here, we report the feasibility of "immuno-OpenPET" as a novel approach enabling not only early diagnosis but also image-guided surgery, using a small (<1 cm) resectable PC orthotopic xenograft mouse model. For immuno-OpenPET, we utilized our original OpenPET system, which enables high-resolution positron emission tomography (PET) imaging with depth-of-interaction detectors, as well as real-time image-guided surgery, by arranging the detectors to create an open space for surgery and accelerating the image reconstruction process by graphics processing units. For immuno-OpenPET, Cu-labeled anti-epidermal growth factor receptor antibody cetuximab was intraperitoneally administered into mice. It clearly identified PC tumors ≥3 mm. In contrast, neither OpenPET with intravenous-administered Cu-cetuximab nor intraperitoneal/intravenous-administered F-FDG (a traditional PET probe) could detect PC in this model. Immuno-OpenPET-guided surgery accurately resected small PC in mice and achieved significantly prolonged survival. This technology could provide a novel diagnostic and therapeutic strategy for small resectable PC to improve patient survival. | |||||
| 書誌情報 |
Scientific reports 巻 10, 号 1, p. 4143, 発行日 2020-03 |
|||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 2045-2322 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 32157106 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41598-020-61056-5 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41598-020-61056-5 | |||||
