@article{oai:repo.qst.go.jp:00079896,
 author = {Yoshii, Yukie and Tashima, Hideaki and Iwao, Yuma and Yoshida, Eiji and Wakizaka, Hidekatsu and Akamatsu, Go and Yamaya, Taiga and Matsumoto, Hiroki and Yoshimoto, Mitsuyoshi and Igarashi, Chika and Hihara, Fukiko and Tachibana, Tomoko and Ming-Rong, Zhang and Nagatsu, Kotaro and Sugyo, Aya and B Tsuji, Atsushi and Higashi, Tatsuya and Yoshii, Yukie and Tashima, Hideaki and Iwao, Yuma and Yoshida, Eiji and Wakizaka, Hidekatsu and Akamatsu, Go and Yamaya, Taiga and Matsumoto, Hiroki and Yoshimoto, Mitsuyoshi and Igarashi, Chika and Hihara, Fukiko and Tachibana, Tomoko and Ming-Rong, Zhang and Nagatsu, Kotaro and Sugyo, Aya and Tsuji, Atsushi and Higashi, Tatsuya},
 issue = {1},
 journal = {Scientific reports},
 month = {Mar},
 note = {Pancreatic cancer (PC) has a poor prognosis owing to difficulties in the diagnosis of resectable PC at early stages. Several clinical studies have indicated that the detection and surgery of small resectable PC (<1 cm) can significantly improve survival; however, imaging diagnosis and accurate resection of small PC remain challenging. Here, we report the feasibility of "immuno-OpenPET" as a novel approach enabling not only early diagnosis but also image-guided surgery, using a small (<1 cm) resectable PC orthotopic xenograft mouse model. For immuno-OpenPET, we utilized our original OpenPET system, which enables high-resolution positron emission tomography (PET) imaging with depth-of-interaction detectors, as well as real-time image-guided surgery, by arranging the detectors to create an open space for surgery and accelerating the image reconstruction process by graphics processing units. For immuno-OpenPET, Cu-labeled anti-epidermal growth factor receptor antibody cetuximab was intraperitoneally administered into mice. It clearly identified PC tumors ≥3 mm. In contrast, neither OpenPET with intravenous-administered Cu-cetuximab nor intraperitoneal/intravenous-administered F-FDG (a traditional PET probe) could detect PC in this model. Immuno-OpenPET-guided surgery accurately resected small PC in mice and achieved significantly prolonged survival. This technology could provide a novel diagnostic and therapeutic strategy for small resectable PC to improve patient survival.},
 title = {Immuno-OpenPET: a novel approach for early diagnosis and image-guided surgery for small resectable pancreatic cancer.},
 volume = {10},
 year = {2020}
}