WEKO3
アイテム
Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice
https://repo.qst.go.jp/records/79887
https://repo.qst.go.jp/records/79887f5dd007f-cef4-46d6-a265-f3955f00bec4
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-04-15 | |||||
| タイトル | ||||||
| タイトル | Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Okawa, Aoi
× Okawa, Aoi× Morioka, Takamitsu× Imaoka, Tatsuhiko× Kakinuma, Shizuko× Matsumoto, Yoshihisa× Aoi, Okawa× Takamitsu, Morioka× Tatsuhiko, Imaoka× Shizuko, Kakinuma× Yoshihisa, Matsumoto |
|||||
| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | It is generally thought that younger people are more susceptible to develop cancer upon ionizing radiation exposure in reference to epidemiological studies and animal experiments. However, little is known about the agedependent alteration in DNA repair ability. In the present study, we examined the expression levels of proteins, which are involved in the repair of DNA double-strand break through non-homologous end joining, i.e., DNAdependent protein kinase catalytic subunit (DNA-PKcs), Xray repair cross-complementing 4 (XRCC4) and XRCC4-like factor (XLF). We found that the expression of DNA-PKcs in the brain tissues was higher in neonatal mice (1 week after birth) than in young adult mice (7 weeks after birth). In association with this, DNA double-strand breaks were repaired more rapidly in the brain tissues of neonatal mice than in those of young adult mice. The current results suggested a possible role for DNA-PKcs protecting developing brain tissues from DNA double-strand breaks. |
|||||
| 書誌情報 |
Proceedings of the Japan Academy, Series B 巻 96, 号 5, p. 171-179, 発行日 2020-04 |
|||||
| 出版者 | ||||||
| 出版者 | The Japan Academy | |||||
| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 0386-2208 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.2183/pjab.96.014 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.jstage.jst.go.jp/article/pjab/96/5/96_PJA9605B-01/_article | |||||
