@article{oai:repo.qst.go.jp:00079887,
 author = {Okawa, Aoi and Morioka, Takamitsu and Imaoka, Tatsuhiko and Kakinuma, Shizuko and Matsumoto, Yoshihisa and Aoi, Okawa and Takamitsu, Morioka and Tatsuhiko, Imaoka and Shizuko, Kakinuma and Yoshihisa, Matsumoto},
 issue = {5},
 journal = {Proceedings of the Japan Academy, Series B},
 month = {Apr},
 note = {It is generally thought that younger people are more
susceptible to develop cancer upon ionizing radiation
exposure in reference to epidemiological studies and animal
experiments. However, little is known about the agedependent
alteration in DNA repair ability. In the present
study, we examined the expression levels of proteins, which
are involved in the repair of DNA double-strand
break through non-homologous end joining, i.e., DNAdependent
protein kinase catalytic subunit (DNA-PKcs), Xray
repair cross-complementing 4 (XRCC4) and XRCC4-like
factor (XLF). We found that the expression of DNA-PKcs in
the brain tissues was higher in neonatal mice (1 week after
birth) than in young adult mice (7 weeks after birth). In
association with this, DNA double-strand breaks were
repaired more rapidly in the brain tissues of neonatal mice
than in those of young adult mice. The current results suggested a possible
role for DNA-PKcs protecting developing brain tissues from
DNA double-strand breaks.},
 pages = {171--179},
 title = {Differential expression of DNA-dependent protein kinase catalytic subunit in the brain of neonatal mice and young adult mice},
 volume = {96},
 year = {2020}
}