{"_buckets": {"deposit": "047da8e1-b344-4117-b5ac-a14dd15c7fd8"}, "_deposit": {"created_by": 1, "id": "79676", "owners": [1], "pid": {"revision_id": 0, "type": "depid", "value": "79676"}, "status": "published"}, "_oai": {"id": "oai:repo.qst.go.jp:00079676", "sets": ["1"]}, "author_link": ["897872", "897857", "897875", "897859", "897858", "897887", "897881", "897868", "897892", "897870", "897894", "897854", "897877", "897879", "897853", "897862", "897863", "897880", "897865", "897878", "897855", "897873", "897874", "897871", "897866", "897884", "897861", "897860", "897864", "897876", "897885", "897888", "897893", "897852", "897890", "897856", "897889", "897882", "897883", "897867", "897869", "897851", "897891", "897886"], "item_8_biblio_info_7": {"attribute_name": "書誌情報", "attribute_value_mlt": [{"bibliographicIssueDates": {"bibliographicIssueDate": "2020-01", "bibliographicIssueDateType": "Issued"}, "bibliographicIssueNumber": "2", "bibliographicPageEnd": "288", "bibliographicPageStart": "281", "bibliographicVolumeNumber": "26", "bibliographic_titles": [{"bibliographic_title": "Nature Medicine"}]}]}, "item_8_description_5": {"attribute_name": "抄録", "attribute_value_mlt": [{"subitem_description": "Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA receptors in the living human brain. Here we developed a positron emission tomography (PET) tracer for AMPA receptors. A derivative of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide radiolabeled with 11C ([11C]K-2) showed specific binding to AMPA receptors. Our clinical trial with healthy human participants confirmed reversible binding of [11C] K-2 in the brain according to Logan graphical analysis (UMIN000020975; study design: non-randomized, single arm; pri- mary outcome: dynamics and distribution volumes of [11C]K-2 in the brain; secondary outcome: adverse events of [11C]K-2 during the 4–10 d following dosing; this trial met prespecified endpoints). In an exploratory clinical study including patients with epilepsy, we detected increased [11C]K-2 uptake in the epileptogenic focus of patients with mesial temporal lobe epi- lepsy, which was closely correlated with the local AMPA receptor protein distribution in surgical specimens from the same individuals (UMIN000025090; study design: non-randomized, single arm; primary outcome: correlation between [11C]K-2 uptake measured with PET before surgery and AMPA receptor protein density examined by biochemical study after surgery; secondary outcome: adverse events during the 7 d following PET scan; this trial met prespecified endpoints). Thus, [11C]K-2 is a potent PET tracer for AMPA receptors, potentially providing a tool to examine the involvement of AMPA receptors in neuropsychiatric disorders.", "subitem_description_type": "Abstract"}]}, "item_8_relation_13": {"attribute_name": "PubMed番号", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "31959988  ", "subitem_relation_type_select": "PMID"}}]}, "item_8_relation_14": {"attribute_name": "DOI", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "10.1038/s41591-019-0723-9", "subitem_relation_type_select": "DOI"}}]}, "item_8_relation_17": {"attribute_name": "関連サイト", "attribute_value_mlt": [{"subitem_relation_type_id": {"subitem_relation_type_id_text": "https://www.nature.com/articles/s41591-019-0723-9", "subitem_relation_type_select": "URI"}}]}, "item_8_source_id_9": {"attribute_name": "ISSN", "attribute_value_mlt": [{"subitem_source_identifier": "1078-8956", "subitem_source_identifier_type": "ISSN"}]}, "item_access_right": {"attribute_name": "アクセス権", "attribute_value_mlt": [{"subitem_access_right": "metadata only access", "subitem_access_right_uri": "http://purl.org/coar/access_right/c_14cb"}]}, "item_creator": {"attribute_name": "著者", "attribute_type": "creator", "attribute_value_mlt": [{"creatorNames": [{"creatorName": "Miyazaki, Tomoyuki"}], "nameIdentifiers": [{"nameIdentifier": "897851", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima, Waki"}], "nameIdentifiers": [{"nameIdentifier": "897852", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hatano, Mai"}], "nameIdentifiers": [{"nameIdentifier": "897853", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Shibata, Yusuke"}], "nameIdentifiers": [{"nameIdentifier": "897854", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kuroki, Yoko"}], "nameIdentifiers": [{"nameIdentifier": "897855", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Arisawa, Tetsu"}], "nameIdentifiers": [{"nameIdentifier": "897856", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Serizawa, Asami"}], "nameIdentifiers": [{"nameIdentifier": "897857", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sano, Akane"}], "nameIdentifiers": [{"nameIdentifier": "897858", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kogami, Sayaka"}], "nameIdentifiers": [{"nameIdentifier": "897859", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamanoue, Tomomi"}], "nameIdentifiers": [{"nameIdentifier": "897860", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Kimito"}], "nameIdentifiers": [{"nameIdentifier": "897861", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Hirata, Yushi"}], "nameIdentifiers": [{"nameIdentifier": "897862", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takada, Yuuki"}], "nameIdentifiers": [{"nameIdentifier": "897863", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ishiwata, Yoshinobu"}], "nameIdentifiers": [{"nameIdentifier": "897864", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Sonoda, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "897865", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tokunaga, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "897866", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie"}], "nameIdentifiers": [{"nameIdentifier": "897867", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagai, Yuji"}], "nameIdentifiers": [{"nameIdentifier": "897868", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minamimoto, Takafumi"}], "nameIdentifiers": [{"nameIdentifier": "897869", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazunori"}], "nameIdentifiers": [{"nameIdentifier": "897870", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang"}], "nameIdentifiers": [{"nameIdentifier": "897871", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ikegaya, Naoki"}], "nameIdentifiers": [{"nameIdentifier": "897872", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Iwasaki, Masaki"}], "nameIdentifiers": [{"nameIdentifier": "897873", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kunii, Naoto"}], "nameIdentifiers": [{"nameIdentifier": "897874", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kimura, Yuichi"}], "nameIdentifiers": [{"nameIdentifier": "897875", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yamashita, Fumio"}], "nameIdentifiers": [{"nameIdentifier": "897876", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Taguri, Masataka"}], "nameIdentifiers": [{"nameIdentifier": "897877", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tani, Hidaaki"}], "nameIdentifiers": [{"nameIdentifier": "897878", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagai, Nobuhiro"}], "nameIdentifiers": [{"nameIdentifier": "897879", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Koizumi, Teruki"}], "nameIdentifiers": [{"nameIdentifier": "897880", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nakajima, Shinichiro"}], "nameIdentifiers": [{"nameIdentifier": "897881", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Mimura, Masaru"}], "nameIdentifiers": [{"nameIdentifier": "897882", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Yuzaki, Michisuke"}], "nameIdentifiers": [{"nameIdentifier": "897883", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kato, Hiroki"}], "nameIdentifiers": [{"nameIdentifier": "897884", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto"}], "nameIdentifiers": [{"nameIdentifier": "897885", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Uchida, Hiroyuki"}], "nameIdentifiers": [{"nameIdentifier": "897886", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Takahashi, Takuya"}], "nameIdentifiers": [{"nameIdentifier": "897887", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Tokunaga, Masaki", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897888", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Seki, Chie", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897889", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Nagai, Yuji", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897890", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Minamimoto, Takafumi", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897891", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Kawamura, Kazunori", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897892", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Ming-Rong, Zhang", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897893", "nameIdentifierScheme": "WEKO"}]}, {"creatorNames": [{"creatorName": "Higuchi, Makoto", "creatorNameLang": "en"}], "nameIdentifiers": [{"nameIdentifier": "897894", "nameIdentifierScheme": "WEKO"}]}]}, "item_language": {"attribute_name": "言語", "attribute_value_mlt": [{"subitem_language": "eng"}]}, "item_resource_type": {"attribute_name": "資源タイプ", "attribute_value_mlt": [{"resourcetype": "journal article", "resourceuri": "http://purl.org/coar/resource_type/c_6501"}]}, "item_title": "Visualization of AMPA receptors in living human brain with positron emission tomography", "item_titles": {"attribute_name": "タイトル", "attribute_value_mlt": [{"subitem_title": "Visualization of AMPA receptors in living human brain with positron emission tomography"}]}, "item_type_id": "8", "owner": "1", "path": ["1"], "permalink_uri": "https://repo.qst.go.jp/records/79676", "pubdate": {"attribute_name": "公開日", "attribute_value": "2020-03-26"}, "publish_date": "2020-03-26", "publish_status": "0", "recid": "79676", "relation": {}, "relation_version_is_last": true, "title": ["Visualization of AMPA receptors in living human brain with positron emission tomography"], "weko_shared_id": -1}