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  1. 原著論文

Visualization of AMPA receptors in living human brain with positron emission tomography

https://repo.qst.go.jp/records/79676
https://repo.qst.go.jp/records/79676
5081c9bc-39a8-4aac-8fd1-2124621b48ce
Item type 学術雑誌論文 / Journal Article(1)
公開日 2020-03-26
タイトル
タイトル Visualization of AMPA receptors in living human brain with positron emission tomography
言語
言語 eng
資源タイプ
資源タイプ識別子 http://purl.org/coar/resource_type/c_6501
資源タイプ journal article
アクセス権
アクセス権 metadata only access
アクセス権URI http://purl.org/coar/access_right/c_14cb
著者 Miyazaki, Tomoyuki

× Miyazaki, Tomoyuki

WEKO 897851

Miyazaki, Tomoyuki

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Nakajima, Waki

× Nakajima, Waki

WEKO 897852

Nakajima, Waki

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Hatano, Mai

× Hatano, Mai

WEKO 897853

Hatano, Mai

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Shibata, Yusuke

× Shibata, Yusuke

WEKO 897854

Shibata, Yusuke

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Kuroki, Yoko

× Kuroki, Yoko

WEKO 897855

Kuroki, Yoko

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Arisawa, Tetsu

× Arisawa, Tetsu

WEKO 897856

Arisawa, Tetsu

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Serizawa, Asami

× Serizawa, Asami

WEKO 897857

Serizawa, Asami

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Sano, Akane

× Sano, Akane

WEKO 897858

Sano, Akane

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Kogami, Sayaka

× Kogami, Sayaka

WEKO 897859

Kogami, Sayaka

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Yamanoue, Tomomi

× Yamanoue, Tomomi

WEKO 897860

Yamanoue, Tomomi

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Kimura, Kimito

× Kimura, Kimito

WEKO 897861

Kimura, Kimito

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Hirata, Yushi

× Hirata, Yushi

WEKO 897862

Hirata, Yushi

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Takada, Yuuki

× Takada, Yuuki

WEKO 897863

Takada, Yuuki

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Ishiwata, Yoshinobu

× Ishiwata, Yoshinobu

WEKO 897864

Ishiwata, Yoshinobu

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Sonoda, Masaki

× Sonoda, Masaki

WEKO 897865

Sonoda, Masaki

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Tokunaga, Masaki

× Tokunaga, Masaki

WEKO 897866

Tokunaga, Masaki

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Seki, Chie

× Seki, Chie

WEKO 897867

Seki, Chie

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Nagai, Yuji

× Nagai, Yuji

WEKO 897868

Nagai, Yuji

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Minamimoto, Takafumi

× Minamimoto, Takafumi

WEKO 897869

Minamimoto, Takafumi

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Kawamura, Kazunori

× Kawamura, Kazunori

WEKO 897870

Kawamura, Kazunori

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Ming-Rong, Zhang

× Ming-Rong, Zhang

WEKO 897871

Ming-Rong, Zhang

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Ikegaya, Naoki

× Ikegaya, Naoki

WEKO 897872

Ikegaya, Naoki

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Iwasaki, Masaki

× Iwasaki, Masaki

WEKO 897873

Iwasaki, Masaki

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Kunii, Naoto

× Kunii, Naoto

WEKO 897874

Kunii, Naoto

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Kimura, Yuichi

× Kimura, Yuichi

WEKO 897875

Kimura, Yuichi

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Yamashita, Fumio

× Yamashita, Fumio

WEKO 897876

Yamashita, Fumio

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Taguri, Masataka

× Taguri, Masataka

WEKO 897877

Taguri, Masataka

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Tani, Hidaaki

× Tani, Hidaaki

WEKO 897878

Tani, Hidaaki

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Nagai, Nobuhiro

× Nagai, Nobuhiro

WEKO 897879

Nagai, Nobuhiro

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Koizumi, Teruki

× Koizumi, Teruki

WEKO 897880

Koizumi, Teruki

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Nakajima, Shinichiro

× Nakajima, Shinichiro

WEKO 897881

Nakajima, Shinichiro

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Mimura, Masaru

× Mimura, Masaru

WEKO 897882

Mimura, Masaru

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Yuzaki, Michisuke

× Yuzaki, Michisuke

WEKO 897883

Yuzaki, Michisuke

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Kato, Hiroki

× Kato, Hiroki

WEKO 897884

Kato, Hiroki

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Higuchi, Makoto

× Higuchi, Makoto

WEKO 897885

Higuchi, Makoto

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Uchida, Hiroyuki

× Uchida, Hiroyuki

WEKO 897886

Uchida, Hiroyuki

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Takahashi, Takuya

× Takahashi, Takuya

WEKO 897887

Takahashi, Takuya

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Tokunaga, Masaki

× Tokunaga, Masaki

WEKO 897888

en Tokunaga, Masaki

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Seki, Chie

× Seki, Chie

WEKO 897889

en Seki, Chie

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Nagai, Yuji

× Nagai, Yuji

WEKO 897890

en Nagai, Yuji

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Minamimoto, Takafumi

× Minamimoto, Takafumi

WEKO 897891

en Minamimoto, Takafumi

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Kawamura, Kazunori

× Kawamura, Kazunori

WEKO 897892

en Kawamura, Kazunori

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Ming-Rong, Zhang

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WEKO 897893

en Ming-Rong, Zhang

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Higuchi, Makoto

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WEKO 897894

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抄録
内容記述タイプ Abstract
内容記述 Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA receptors in the living human brain. Here we developed a positron emission tomography (PET) tracer for AMPA receptors. A derivative of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide radiolabeled with 11C ([11C]K-2) showed specific binding to AMPA receptors. Our clinical trial with healthy human participants confirmed reversible binding of [11C] K-2 in the brain according to Logan graphical analysis (UMIN000020975; study design: non-randomized, single arm; pri- mary outcome: dynamics and distribution volumes of [11C]K-2 in the brain; secondary outcome: adverse events of [11C]K-2 during the 4–10 d following dosing; this trial met prespecified endpoints). In an exploratory clinical study including patients with epilepsy, we detected increased [11C]K-2 uptake in the epileptogenic focus of patients with mesial temporal lobe epi- lepsy, which was closely correlated with the local AMPA receptor protein distribution in surgical specimens from the same individuals (UMIN000025090; study design: non-randomized, single arm; primary outcome: correlation between [11C]K-2 uptake measured with PET before surgery and AMPA receptor protein density examined by biochemical study after surgery; secondary outcome: adverse events during the 7 d following PET scan; this trial met prespecified endpoints). Thus, [11C]K-2 is a potent PET tracer for AMPA receptors, potentially providing a tool to examine the involvement of AMPA receptors in neuropsychiatric disorders.
書誌情報 Nature Medicine

巻 26, 号 2, p. 281-288, 発行日 2020-01
ISSN
収録物識別子タイプ ISSN
収録物識別子 1078-8956
PubMed番号
識別子タイプ PMID
関連識別子 31959988
DOI
識別子タイプ DOI
関連識別子 10.1038/s41591-019-0723-9
関連サイト
識別子タイプ URI
関連識別子 https://www.nature.com/articles/s41591-019-0723-9
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