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Visualization of AMPA receptors in living human brain with positron emission tomography
https://repo.qst.go.jp/records/79676
https://repo.qst.go.jp/records/796765081c9bc-39a8-4aac-8fd1-2124621b48ce
| Item type | 学術雑誌論文 / Journal Article(1) | |||||
|---|---|---|---|---|---|---|
| 公開日 | 2020-03-26 | |||||
| タイトル | ||||||
| タイトル | Visualization of AMPA receptors in living human brain with positron emission tomography | |||||
| 言語 | ||||||
| 言語 | eng | |||||
| 資源タイプ | ||||||
| 資源タイプ識別子 | http://purl.org/coar/resource_type/c_6501 | |||||
| 資源タイプ | journal article | |||||
| アクセス権 | ||||||
| アクセス権 | metadata only access | |||||
| アクセス権URI | http://purl.org/coar/access_right/c_14cb | |||||
| 著者 |
Miyazaki, Tomoyuki
× Miyazaki, Tomoyuki× Nakajima, Waki× Hatano, Mai× Shibata, Yusuke× Kuroki, Yoko× Arisawa, Tetsu× Serizawa, Asami× Sano, Akane× Kogami, Sayaka× Yamanoue, Tomomi× Kimura, Kimito× Hirata, Yushi× Takada, Yuuki× Ishiwata, Yoshinobu× Sonoda, Masaki× Tokunaga, Masaki× Seki, Chie× Nagai, Yuji× Minamimoto, Takafumi× Kawamura, Kazunori× Ming-Rong, Zhang× Ikegaya, Naoki× Iwasaki, Masaki× Kunii, Naoto× Kimura, Yuichi× Yamashita, Fumio× Taguri, Masataka× Tani, Hidaaki× Nagai, Nobuhiro× Koizumi, Teruki× Nakajima, Shinichiro× Mimura, Masaru× Yuzaki, Michisuke× Kato, Hiroki× Higuchi, Makoto× Uchida, Hiroyuki× Takahashi, Takuya× Tokunaga, Masaki× Seki, Chie× Nagai, Yuji× Minamimoto, Takafumi× Kawamura, Kazunori× Ming-Rong, Zhang× Higuchi, Makoto |
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| 抄録 | ||||||
| 内容記述タイプ | Abstract | |||||
| 内容記述 | Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA receptors in the living human brain. Here we developed a positron emission tomography (PET) tracer for AMPA receptors. A derivative of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide radiolabeled with 11C ([11C]K-2) showed specific binding to AMPA receptors. Our clinical trial with healthy human participants confirmed reversible binding of [11C] K-2 in the brain according to Logan graphical analysis (UMIN000020975; study design: non-randomized, single arm; pri- mary outcome: dynamics and distribution volumes of [11C]K-2 in the brain; secondary outcome: adverse events of [11C]K-2 during the 4–10 d following dosing; this trial met prespecified endpoints). In an exploratory clinical study including patients with epilepsy, we detected increased [11C]K-2 uptake in the epileptogenic focus of patients with mesial temporal lobe epi- lepsy, which was closely correlated with the local AMPA receptor protein distribution in surgical specimens from the same individuals (UMIN000025090; study design: non-randomized, single arm; primary outcome: correlation between [11C]K-2 uptake measured with PET before surgery and AMPA receptor protein density examined by biochemical study after surgery; secondary outcome: adverse events during the 7 d following PET scan; this trial met prespecified endpoints). Thus, [11C]K-2 is a potent PET tracer for AMPA receptors, potentially providing a tool to examine the involvement of AMPA receptors in neuropsychiatric disorders. | |||||
| 書誌情報 |
Nature Medicine 巻 26, 号 2, p. 281-288, 発行日 2020-01 |
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| ISSN | ||||||
| 収録物識別子タイプ | ISSN | |||||
| 収録物識別子 | 1078-8956 | |||||
| PubMed番号 | ||||||
| 識別子タイプ | PMID | |||||
| 関連識別子 | 31959988 | |||||
| DOI | ||||||
| 識別子タイプ | DOI | |||||
| 関連識別子 | 10.1038/s41591-019-0723-9 | |||||
| 関連サイト | ||||||
| 識別子タイプ | URI | |||||
| 関連識別子 | https://www.nature.com/articles/s41591-019-0723-9 | |||||
