{"created":"2023-05-15T14:58:43.826183+00:00","id":79676,"links":{},"metadata":{"_buckets":{"deposit":"047da8e1-b344-4117-b5ac-a14dd15c7fd8"},"_deposit":{"created_by":1,"id":"79676","owners":[1],"pid":{"revision_id":0,"type":"depid","value":"79676"},"status":"published"},"_oai":{"id":"oai:repo.qst.go.jp:00079676","sets":["1"]},"author_link":["897872","897857","897875","897859","897858","897887","897881","897868","897892","897870","897894","897854","897877","897879","897853","897862","897863","897880","897865","897878","897855","897873","897874","897871","897866","897884","897861","897860","897864","897876","897885","897888","897893","897852","897890","897856","897889","897882","897883","897867","897869","897851","897891","897886"],"item_8_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2020-01","bibliographicIssueDateType":"Issued"},"bibliographicIssueNumber":"2","bibliographicPageEnd":"288","bibliographicPageStart":"281","bibliographicVolumeNumber":"26","bibliographic_titles":[{"bibliographic_title":"Nature Medicine"}]}]},"item_8_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"Although aberrations in the number and function of glutamate AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors are thought to underlie neuropsychiatric disorders, no methods are currently available for visualizing AMPA receptors in the living human brain. Here we developed a positron emission tomography (PET) tracer for AMPA receptors. A derivative of 4-[2-(phenylsulfonylamino)ethylthio]-2,6-difluoro-phenoxyacetamide radiolabeled with 11C ([11C]K-2) showed specific binding to AMPA receptors. Our clinical trial with healthy human participants confirmed reversible binding of [11C] K-2 in the brain according to Logan graphical analysis (UMIN000020975; study design: non-randomized, single arm; pri- mary outcome: dynamics and distribution volumes of [11C]K-2 in the brain; secondary outcome: adverse events of [11C]K-2 during the 4–10 d following dosing; this trial met prespecified endpoints). In an exploratory clinical study including patients with epilepsy, we detected increased [11C]K-2 uptake in the epileptogenic focus of patients with mesial temporal lobe epi- lepsy, which was closely correlated with the local AMPA receptor protein distribution in surgical specimens from the same individuals (UMIN000025090; study design: non-randomized, single arm; primary outcome: correlation between [11C]K-2 uptake measured with PET before surgery and AMPA receptor protein density examined by biochemical study after surgery; secondary outcome: adverse events during the 7 d following PET scan; this trial met prespecified endpoints). Thus, [11C]K-2 is a potent PET tracer for AMPA receptors, potentially providing a tool to examine the involvement of AMPA receptors in neuropsychiatric disorders.","subitem_description_type":"Abstract"}]},"item_8_relation_13":{"attribute_name":"PubMed番号","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"31959988  ","subitem_relation_type_select":"PMID"}}]},"item_8_relation_14":{"attribute_name":"DOI","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"10.1038/s41591-019-0723-9","subitem_relation_type_select":"DOI"}}]},"item_8_relation_17":{"attribute_name":"関連サイト","attribute_value_mlt":[{"subitem_relation_type_id":{"subitem_relation_type_id_text":"https://www.nature.com/articles/s41591-019-0723-9","subitem_relation_type_select":"URI"}}]},"item_8_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1078-8956","subitem_source_identifier_type":"ISSN"}]},"item_access_right":{"attribute_name":"アクセス権","attribute_value_mlt":[{"subitem_access_right":"metadata only access","subitem_access_right_uri":"http://purl.org/coar/access_right/c_14cb"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"Miyazaki, Tomoyuki"}],"nameIdentifiers":[{"nameIdentifier":"897851","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Waki"}],"nameIdentifiers":[{"nameIdentifier":"897852","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hatano, Mai"}],"nameIdentifiers":[{"nameIdentifier":"897853","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Shibata, Yusuke"}],"nameIdentifiers":[{"nameIdentifier":"897854","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kuroki, Yoko"}],"nameIdentifiers":[{"nameIdentifier":"897855","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Arisawa, Tetsu"}],"nameIdentifiers":[{"nameIdentifier":"897856","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Serizawa, Asami"}],"nameIdentifiers":[{"nameIdentifier":"897857","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sano, Akane"}],"nameIdentifiers":[{"nameIdentifier":"897858","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kogami, Sayaka"}],"nameIdentifiers":[{"nameIdentifier":"897859","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamanoue, Tomomi"}],"nameIdentifiers":[{"nameIdentifier":"897860","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Kimito"}],"nameIdentifiers":[{"nameIdentifier":"897861","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Hirata, Yushi"}],"nameIdentifiers":[{"nameIdentifier":"897862","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takada, Yuuki"}],"nameIdentifiers":[{"nameIdentifier":"897863","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ishiwata, Yoshinobu"}],"nameIdentifiers":[{"nameIdentifier":"897864","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Sonoda, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"897865","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"897866","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie"}],"nameIdentifiers":[{"nameIdentifier":"897867","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Yuji"}],"nameIdentifiers":[{"nameIdentifier":"897868","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi"}],"nameIdentifiers":[{"nameIdentifier":"897869","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori"}],"nameIdentifiers":[{"nameIdentifier":"897870","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang"}],"nameIdentifiers":[{"nameIdentifier":"897871","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ikegaya, Naoki"}],"nameIdentifiers":[{"nameIdentifier":"897872","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Iwasaki, Masaki"}],"nameIdentifiers":[{"nameIdentifier":"897873","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kunii, Naoto"}],"nameIdentifiers":[{"nameIdentifier":"897874","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kimura, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"897875","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yamashita, Fumio"}],"nameIdentifiers":[{"nameIdentifier":"897876","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Taguri, Masataka"}],"nameIdentifiers":[{"nameIdentifier":"897877","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tani, Hidaaki"}],"nameIdentifiers":[{"nameIdentifier":"897878","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Nobuhiro"}],"nameIdentifiers":[{"nameIdentifier":"897879","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Koizumi, Teruki"}],"nameIdentifiers":[{"nameIdentifier":"897880","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nakajima, Shinichiro"}],"nameIdentifiers":[{"nameIdentifier":"897881","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Mimura, Masaru"}],"nameIdentifiers":[{"nameIdentifier":"897882","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Yuzaki, Michisuke"}],"nameIdentifiers":[{"nameIdentifier":"897883","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kato, Hiroki"}],"nameIdentifiers":[{"nameIdentifier":"897884","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto"}],"nameIdentifiers":[{"nameIdentifier":"897885","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Uchida, Hiroyuki"}],"nameIdentifiers":[{"nameIdentifier":"897886","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Takahashi, Takuya"}],"nameIdentifiers":[{"nameIdentifier":"897887","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Tokunaga, Masaki","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897888","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Seki, Chie","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897889","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Nagai, Yuji","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897890","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Minamimoto, Takafumi","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897891","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Kawamura, Kazunori","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897892","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Ming-Rong, Zhang","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897893","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"Higuchi, Makoto","creatorNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"897894","nameIdentifierScheme":"WEKO"}]}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"journal article","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"Visualization of AMPA receptors in living human brain with positron emission tomography","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"Visualization of AMPA receptors in living human brain with positron emission tomography"}]},"item_type_id":"8","owner":"1","path":["1"],"pubdate":{"attribute_name":"公開日","attribute_value":"2020-03-26"},"publish_date":"2020-03-26","publish_status":"0","recid":"79676","relation_version_is_last":true,"title":["Visualization of AMPA receptors in living human brain with positron emission tomography"],"weko_creator_id":"1","weko_shared_id":-1},"updated":"2023-05-15T21:21:32.597677+00:00"}